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Dermatoscopic and clinical features of congenital or congenital-type nail matrix nevi: A multicenter prospective cohort study by the International Dermoscopy Society

Cited 0 time in Web of Science Cited 4 time in Scopus
Authors

Pham, Félix; Boespflug, Amélie; Duru, Gérard; Phan, Alice; Poulalhon, Nicolas; Weiler, Laura; Tanaka, Masaru; Lallas, Aimilios; Ogata, Dai; Davaine, Anne Céline; Bahadoran, Philippe; Balguerie, Xavier; Kamińska-Winciorek, Grażyna; Tromme, Isabelle; Correia, Osvaldo; Kim, Moon-Bum; Marghoob, Ashfaq A.; Linda, Martin; Guitera, Pascale; Meziane, Mariame; Miquel, Juliette; Mun, Je-Ho; Argenziano, Giuseppe; Bessis, Didier; Bourke, Johnny; Mijuskovic, Zeljko; Chiaverini, Christine; Corven-Benoit, Cloé; Droitcourt, Catherine; Skowron, François; Marque, Myriam; Zalaudek, Iris; Rosendahl, Cliff; Moreno-Ramirez, David; Vabres, Pierre; Haenssle, Holger; Malvehy, Josep; Puig, Susana; Robert, Caroline; Schopf, Thomas R.; Scope, Alon; Dalle, Stéphane; Thomas, Luc

Issue Date
2022-01
Publisher
Mosby Inc.
Citation
Journal of the American Academy of Dermatology
Abstract
© 2022Background: Congenital nail matrix nevi (NMN) are difficult to diagnose because they feature clinical characteristics suggestive of adult subungual melanoma. Nail matrix biopsy is difficult to perform, especially in children. Objective: To describe the initial clinical and dermatoscopic features of NMN appearing at birth (congenital) or after birth but before the age of 5 years (congenital-type). Methods: We conducted a prospective, international, and consecutive data collection in 102 hospitals or private medical offices across 30 countries from 2009 to 2019. Results: There were 69 congenital and 161 congenital-type NMNs. Congenital and congenital-type NMN predominantly displayed an irregular pattern of longitudinal microlines (n = 146, 64%), reminiscent of subungual melanoma in adults. The distal fibrillar (brush-like) pattern, present in 63 patients (27.8%), was more frequently encountered in congenital NMN than in congenital-type NMN (P = .012). Moreover, congenital NMN more frequently displayed a periungual pigmentation (P = .029) and Hutchinson's sign (P = .027) than did congenital-type NMN. Limitations: Lack of systematic biopsy-proven diagnosis and heterogeneity of clinical and dermatoscopic photographs. Conclusion: Congenital and congenital-type NMN showed worrisome clinical and dermatoscopic features similar to those observed in adulthood subungual melanoma. The distal fibrillar (brush-like) pattern is a suggestive feature of congenital and congenital-type NMN.
ISSN
0190-9622
URI
https://hdl.handle.net/10371/183998
DOI
https://doi.org/10.1016/j.jaad.2022.01.028
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