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Effects of Dose Titration on Dipyridamole-Induced Headache: A Randomized, Double-Blind Clinical Trial
DC Field | Value | Language |
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dc.contributor.author | Kang, Min Kyoung | - |
dc.contributor.author | Cha, Jae-Kwan | - |
dc.contributor.author | Chang, Dae-Il | - |
dc.contributor.author | Kim, Hyun Young | - |
dc.contributor.author | Chung, Jong-Won | - |
dc.contributor.author | Jung, Keun-Hwa | - |
dc.contributor.author | Hong, Keun-Sik | - |
dc.contributor.author | Chang, Jun Young | - |
dc.contributor.author | Rha, Joung-Ho | - |
dc.contributor.author | Park, Jong-Moo | - |
dc.contributor.author | Kim, Byung-Kun | - |
dc.contributor.author | Lee, Soo Joo | - |
dc.contributor.author | Park, Man-Seok | - |
dc.contributor.author | Lee, Kyung-Yul | - |
dc.contributor.author | Shin, Dong-Ick | - |
dc.contributor.author | Yoon, Byung-Woo | - |
dc.date.accessioned | 2022-06-24T08:26:53Z | - |
dc.date.available | 2022-06-24T08:26:53Z | - |
dc.date.created | 2022-05-13 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.citation | Cerebrovascular Diseases | - |
dc.identifier.issn | 1015-9770 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184084 | - |
dc.description.abstract | © 2022 S. Karger AG, Basel. All rights reserved.Purpose: The aim of this study is to investigate the effect of gradual dipyridamole titration and the incidence of dipyridamole-induced headache in patients with ischemic stroke or transient ischemic attack (TIA). Methods: A randomized, double-blind, double-placebo, parallel group, phase 4 clinical trial (KCT0005457) was conducted between July 1, 2019, and February 25, 2020, at 15 medical centers in South Korea. The study included patients aged >19 years diagnosed with a noncardioembolic ischemic stroke or TIA within the previous 3 weeks. The participants were randomized 1:1:1 to receive Adinox® (aspirin 25 mg/dipyridamole 200 mg) and aspirin (100 mg) once daily for the first 2 weeks followed by Adinox® twice daily for 2 weeks (titration group), Adinox® twice daily for 4 weeks (standard group), and aspirin 100 mg once daily for 4 weeks (control group). The primary endpoint was incidence of headache over 4 weeks. The key secondary endpoint was mean cumulative headache. Results: Ninety-six patients were randomized into the titration (n = 31), standard (n = 32), and control (n = 33) groups. The titration and standard groups (74.1% vs. 74.2%, respectively) showed no difference in the primary endpoint. However, the mean cumulated headache was significantly lower in the titration group than in the standard group (0.31 ± 0.46 vs. 0.58 ± 0.51, p = 0.023). Further, adverse drug reactions were more common in the standard group than in the titration group (28.1% vs. 9.7%, respectively, p = 0.054), although not significantly different. Conclusion: The titration strategy was effective in lowering the incidence of cumulative dipyridamole-induced headache. | - |
dc.language | 영어 | - |
dc.publisher | S. Karger AG | - |
dc.title | Effects of Dose Titration on Dipyridamole-Induced Headache: A Randomized, Double-Blind Clinical Trial | - |
dc.type | Article | - |
dc.identifier.doi | 10.1159/000521083 | - |
dc.citation.journaltitle | Cerebrovascular Diseases | - |
dc.identifier.wosid | 000757608600001 | - |
dc.identifier.scopusid | 2-s2.0-85124001238 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Yoon, Byung-Woo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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