Publications
Detailed Information
A theory-based practical solution to correct for sex-differential participation bias
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hanbin | - |
dc.contributor.author | Han, Buhm | - |
dc.date.accessioned | 2022-08-06T07:02:27Z | - |
dc.date.available | 2022-08-06T16:07:04Z | - |
dc.date.issued | 2022-06-27 | - |
dc.identifier.citation | Genome Biology, 23(1):138 | ko_KR |
dc.identifier.issn | 1474-760X | - |
dc.identifier.uri | https://doi.org/10.1186/s13059-022-02703-0 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184236 | - |
dc.description.abstract | Most genomic cohorts are retrospective where the exposures and outcomes are predetermined prior to sample collection. Therefore, a spurious association between an exposure and an outcome can arise if both variables affect study participation. Such concerns were raised in previous studies questioning the representativeness of the UK Biobank. Recently, a genome-wide association study (GWAS) on biological sex found many autosomal hits and non-negligible autosomal heritability which the authors attribute to selection bias. In this study, we propose a simple and a practical method that can overcome sex-driven selection bias based on theoretical analysis and simulations. | ko_KR |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) (Grant number 2022R1A2B5B02001897) funded by the Korean government, Ministry of Science, and ICT. This study was supported by the Creative-Pioneering Researchers Program funded by Seoul National University (SNU). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.title | A theory-based practical solution to correct for sex-differential participation bias | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1186/s13059-022-02703-0 | ko_KR |
dc.citation.journaltitle | Genome Biology | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2022-07-03T03:13:40Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 138 | ko_KR |
dc.citation.volume | 23 | ko_KR |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.