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Laboratory information management system for COVID-19 non-clinical efficacy trial data

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Issue Date
2022-06-28
Publisher
BMC
Citation
Laboratory Animal Research, 38(1):17
Keywords
SARS-CoV-2COVID-19Non-clinicalLaboratory information management systemData
Abstract
Background : As the number of large-scale studies involving multiple organizations producing data has steadily increased, an integrated system for a common interoperable format is needed. In response to the coronavirus disease 2019 (COVID-19) pandemic, a number of global efforts are underway to develop vaccines and therapeutics. We are therefore observing an explosion in the proliferation of COVID-19 data, and interoperability is highly requested in multiple institutions participating simultaneously in COVID-19 pandemic research.
Results : In this study, a laboratory information management system (LIMS) approach has been adopted to systemically manage various COVID-19 non-clinical trial data, including mortality, clinical signs, body weight, body temperature, organ weights, viral titer (viral replication and viral RNA), and multiorgan histopathology, from multiple institutions based on a web interface. The main aim of the implemented system is to integrate, standardize, and organize data collected from laboratories in multiple institutes for COVID-19 non-clinical efficacy testings. Six animal biosafety level 3 institutions proved the feasibility of our system. Substantial benefits were shown by maximizing collaborative high-quality non-clinical research.
Conclusions : This LIMS platform can be used for future outbreaks, leading to accelerated medical product development through the systematic management of extensive data from non-clinical animal studies.
ISSN
2233-7660
Language
English
URI
https://doi.org/10.1186/s42826-022-00127-2

https://hdl.handle.net/10371/184241
DOI
https://doi.org/10.1186/s42826-022-00127-2
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Graduate School of Public Health (보건대학원)Institute of Health and Environment (보건환경연구소)Journal Papers (저널논문_보건환경연구소)
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