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Humulus japonicus attenuates LPS-and scopolamine-induced cognitive impairment in mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Go, Jun | - |
dc.contributor.author | Park, Hye-Yeon | - |
dc.contributor.author | Lee, Da Woon | - |
dc.contributor.author | Maeng, So-Young | - |
dc.contributor.author | Lee, In-Bok | - |
dc.contributor.author | Seo, Yun Jeong | - |
dc.contributor.author | An, Jin-Pyo | - |
dc.contributor.author | Oh, Won Keun | - |
dc.contributor.author | Lee, Chul-Ho | - |
dc.contributor.author | Kim, Kyoung-Shim | - |
dc.date.accessioned | 2022-08-13T05:14:49Z | - |
dc.date.available | 2022-08-13T14:17:50Z | - |
dc.date.issued | 2022-07-19 | - |
dc.identifier.citation | Laboratory Animal Research, 38(1):21 | ko_KR |
dc.identifier.issn | 2233-7660 | - |
dc.identifier.uri | https://doi.org/10.1186/s42826-022-00134-3 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184258 | - |
dc.description.abstract | Background : Neuroinflammation plays an important role in cognitive decline and memory impairment in neurodegenerative disorders. Previously, we demonstrated that Humulus japonicus (HJ) has anti-inflammatory effects in rodent models of Alzheimers disease and Parkinsons disease. The present study aimed to examine the protective potential of HJ extracts against lipopolysaccharide (LPS)-induced cognitive impairment and scopolamine-induced amnesia in mouse models. Cognitive improvement of mice was investigated by novel object recognition test. For analyzing effects on neuroinflammation, immunohistochemistry and quantitative real-time polymerase chain reaction (qRT-PCR) assays were performed.
Results : We found that the oral administration of HJ significantly improved cognitive dysfunction induced by LPS in a novel object recognition test. The LPS-induced activation of microglia was notably decreased by HJ treatment in the cortex and hippocampus. HJ administration with LPS also significantly increased the mRNA expression of interleukin (IL)-10 and decreased the mRNA expression of IL-12 in the parietal cortex of mice. The increased expression of LPS-induced complement C1q B chain (C1bq) and triggering receptor expressed on myeloid cells 2 (Trem2) genes was significantly suppressed by HJ treatment. In addition, HJ administration significantly improved novel object recognition in a scopolamine-induced amnesia mouse model. Conclusions : These findings revealed that HJ has a beneficial effect on cognitive impairment and neuroinflammation induced by systemic inflammation and on amnesia induced by scopolamine in mice. | ko_KR |
dc.description.sponsorship | This study was supported by the KRIBB Research Initiative Program of the Republic of Korea (KGS1042221) and the Development of Platform Technology for Innovative Medical
Measurements funded by Korea Research Institute of Standards and Science (KRISS-GP2022-2). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Humulus japonicas | - |
dc.subject | Cognitive function | - |
dc.subject | Neuroinfammation | - |
dc.subject | Mouse model | - |
dc.title | Humulus japonicus attenuates LPS-and scopolamine-induced cognitive impairment in mice | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1186/s42826-022-00134-3 | ko_KR |
dc.citation.journaltitle | Laboratory Animal Research | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2022-07-25T07:37:03Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 21 | ko_KR |
dc.citation.volume | 38 | ko_KR |
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