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Blockade of Four-Transmembrane L6 Family Member 5 (TM4SF5)-Mediated Tumorigenicity in Hepatocytes by a Synthetic Chalcone Derivative
DC Field | Value | Language |
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dc.contributor.author | Lee, Sin-Ae | - |
dc.contributor.author | Ryu, Hyung Won | - |
dc.contributor.author | Kim, Young Mee | - |
dc.contributor.author | Choi, Suyong | - |
dc.contributor.author | Lee, Mi Ji | - |
dc.contributor.author | Kwak, Tae Kyoung | - |
dc.contributor.author | Kim, Hyeon Jung | - |
dc.contributor.author | Cho, Moonjae | - |
dc.contributor.author | Park, Ki Hun | - |
dc.contributor.author | Lee, Jung Weon | - |
dc.date.accessioned | 2022-08-22T09:05:35Z | - |
dc.date.available | 2022-08-22T09:05:35Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2009-04 | - |
dc.identifier.citation | Hepatology, Vol.49 No.4, pp.1316-1325 | - |
dc.identifier.issn | 0270-9139 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184286 | - |
dc.description.abstract | We previously reported that the four-transmembrane L6 family member 5 (TM4SF5) was highly expressed in hepatocarcinoma, induced morphological elongation and epithelial-mesenchymal transition, and caused abnormal cell growth in multilayers in vitro and tumor formation in vivo. In this study, we identified a synthetic compound, 4'-(p-toluenesulfonylamido)-4-hydroxychalcone (TSAHC) that antagonized both the TM4SF5-mediated multilayer growth and TM4SF5-enhanced migration/invasion. TSAHC treatment induced multilayer-growing cells to grow in monolayers, recovering contact inhibition without accompanying apoptosis, and inhibited chemotactic migration and invasion. Tumor formation in nude mice injected with TM4SF5-expressing cells and the growth of cells expressing endogenous TM4SF5, but not of TM4SF5-null cells, was suppressed by treatment with TSAHC, but not by treatment with its analogs. The structure-activity relationship indicated the significance of 4'-p-toluenesulfonylamido and 4-hydroxy groups for the anti-TM4SF5 effects of TSAHC. Point mutations of the putative N-glycosylation sites abolished the TM4SF5-specific TSAHC responsiveness. Conclusion: These observations suggest that TM4SF5-enhanced tumorigenic proliferation and metastatic potential can be blocked by TSAHC, likely through targeting the extracellular region of TM4SF5, which is important for protein-protein interactions. (HEPATOLOGY 2009;49:1316-1325.) | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | Blockade of Four-Transmembrane L6 Family Member 5 (TM4SF5)-Mediated Tumorigenicity in Hepatocytes by a Synthetic Chalcone Derivative | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/hep.22777 | - |
dc.citation.journaltitle | Hepatology | - |
dc.identifier.wosid | 000264862100029 | - |
dc.identifier.scopusid | 2-s2.0-65449132740 | - |
dc.citation.endpage | 1325 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 1316 | - |
dc.citation.volume | 49 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Jung Weon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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