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Impact of imatinib administration on the mouse ovarian follicle count and levels of intra-ovarian proteins related to follicular quality
DC Field | Value | Language |
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dc.contributor.author | Kim, Se Jeong | - |
dc.contributor.author | Kim, Tae Eun | - |
dc.contributor.author | Jee, Byung Chul | - |
dc.date.accessioned | 2022-08-25T01:14:15Z | - |
dc.date.available | 2022-08-25T01:14:15Z | - |
dc.date.created | 2022-06-27 | - |
dc.date.issued | 2022-06 | - |
dc.identifier.citation | Clinical and Experimental Reproductive Medicine, Vol.49 No.2, pp.93-100 | - |
dc.identifier.issn | 2233-8233 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184388 | - |
dc.description.abstract | Objective: The impact of imatinib, a tyrosine kinase inhibitor, on ovarian follicles and several proteins related to follicular function and apoptosis was investigated in mice. Methods: Saline, cyclophosphamide (Cp; 50 or 75 mg/kg), or imatinib (7.5 or 15 mg/kg) was injected once intraperitoneally into female B6D2F1 mice (18 mice in each group). In multiple ovarian sections, the number of various types of follicles and the proportion of good-quality (G1) follicles were counted. The levels of six proteins (anti-Mullerian hormone [AMH], BCL-xL, BAX, acid sphingomyelinase [A-SMase], caspase-3, and alpha-smooth muscle actin [alpha-SMA]) within the whole ovaries were quantified using Western blots. Results: Compared to the saline group, a significant reduction of the primordial follicle count was observed in the group treated with imatinib 7.5 and 15 mg/kg, as well as in the group treated with Cp 75 mg/kg. Administration of Cp significantly decreased the proportion of G1 primordial follicles, but administration of imatinib did not. No differences in the AMH, anti-apoptotic BCLX-L, pro-apoptotic BAX, and A-SMase levels in the ovarian tissues were observed among the five groups. However, caspase-3 and alpha-SMA levels were significantly higher in the imatinib and Cp groups than in the saline group. Conclusion: The administration of imatinib to mice significantly reduced the primordial follicle count and increased the protein levels of caspase-3 and alpha-SMA. Our findings suggest that imatinib potentially exerts ovarian toxicity via apoptotic processes, similarly to Cp. | - |
dc.language | 영어 | - |
dc.publisher | 대한생식의학회 | - |
dc.title | Impact of imatinib administration on the mouse ovarian follicle count and levels of intra-ovarian proteins related to follicular quality | - |
dc.type | Article | - |
dc.identifier.doi | 10.5653/cerm.2022.05218 | - |
dc.citation.journaltitle | Clinical and Experimental Reproductive Medicine | - |
dc.identifier.wosid | 000808535900004 | - |
dc.citation.endpage | 100 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 93 | - |
dc.citation.volume | 49 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Jee, Byung Chul | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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