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Association of vitamin D status with COVID-19 and its severity: Vitamin D and COVID-19: a narrative review
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bae, Jae Hyun | - |
dc.contributor.author | Choe, Hun Jee | - |
dc.contributor.author | Holick, Michael F. | - |
dc.contributor.author | Lim, Soo | - |
dc.date.accessioned | 2022-08-25T01:14:37Z | - |
dc.date.available | 2022-08-25T01:14:37Z | - |
dc.date.created | 2022-05-20 | - |
dc.date.issued | 2022-06 | - |
dc.identifier.citation | Reviews in Endocrine and Metabolic Disorders, Vol.23 No.3, pp.579-599 | - |
dc.identifier.issn | 1389-9155 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184417 | - |
dc.description.abstract | © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.Vitamin D is associated with biological activities of the innate and adaptive immune systems, as well as inflammation. In observational studies, an inverse relationship has been found between serum 25-hydroxyvitamin D (25(OH)D) concentrations and the risk or severity of coronavirus disease 2019 (COVID-19). Several mechanisms have been proposed for the role of vitamin D in COVID-19, including modulation of immune and inflammatory responses, regulation of the renin–angiotensin–aldosterone system, and involvement in glucose metabolism and cardiovascular system. Low 25(OH)D concentrations might predispose patients with COVID-19 to severe outcomes not only via the associated hyperinflammatory syndrome but also by worsening preexisting impaired glucose metabolism and cardiovascular diseases. Some randomized controlled trials have shown that vitamin D supplementation is beneficial for reducing severe acute respiratory syndrome coronavirus 2 RNA positivity but not for reducing intensive care unit admission or all-cause mortality in patients with moderate-to-severe COVID-19. Current evidence suggests that taking a vitamin D supplement to maintain a serum concentration of 25(OH)D of at least 30 ng/mL (preferred range 40–60 ng/mL), can help reduce the risk of COVID-19 and its severe outcomes, including mortality. Although further well designed studies are warranted, it is prudent to recommend vitamin D supplements to people with vitamin D deficiency/insufficiency during the COVID-19 pandemic according to international guidelines. | - |
dc.language | 영어 | - |
dc.publisher | Kluwer Academic Publishers | - |
dc.title | Association of vitamin D status with COVID-19 and its severity: Vitamin D and COVID-19: a narrative review | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s11154-021-09705-6 | - |
dc.citation.journaltitle | Reviews in Endocrine and Metabolic Disorders | - |
dc.identifier.scopusid | 2-s2.0-85122249271 | - |
dc.citation.endpage | 599 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 579 | - |
dc.citation.volume | 23 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lim, Soo | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
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