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Evaluation of the synergistic impact of needle and forceps biopsy with electromagnetic navigation bronchoscopy: the CONFIDENT-ENB trial design

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dc.contributor.authorKim, Yeon Wook-
dc.contributor.authorKim, Hyung-Jun-
dc.contributor.authorYoon, Sung Hyun-
dc.contributor.authorLee, Kyung Hee-
dc.contributor.authorPark, Young Mi-
dc.contributor.authorAhn, So Yeon-
dc.contributor.authorSong, Myung Jin-
dc.contributor.authorKwon, Byoung Soo-
dc.contributor.authorLim, Sung Yoon-
dc.contributor.authorLee, Yeon Joo-
dc.contributor.authorPark, Jong Sun-
dc.contributor.authorCho, Young-Jae-
dc.contributor.authorYoon, Ho Il-
dc.contributor.authorLee, Jae Ho-
dc.contributor.authorLee, Choon-Taek-
dc.date.accessioned2022-09-16T11:36:21Z-
dc.date.available2022-09-16T20:38:53Z-
dc.date.issued2022-08-19-
dc.identifier.citationBMC Pulmonary Medicine, 22(1):319ko_KR
dc.identifier.issn1471-2466-
dc.identifier.urihttps://doi.org/10.1186/s12890-022-02104-w-
dc.identifier.urihttps://hdl.handle.net/10371/184481-
dc.description.abstractBackground : Electromagnetic navigation bronchoscopy (ENB) is an emerging advanced imaging-guided bronchoscopy technique for diagnosing peripheral lung lesions. However, the selection strategy for the optimal biopsy device and whether adopting a multi-tool strategy increases the diagnostic yield remains undetermined. The CONFIDENT-ENB trial (NCT05110131) is a prospective randomized study on ENB, performed in a least-invasive setting. The primary aim is to evaluate whether a combination of needle aspiration and forceps biopsy improves the diagnostic performance, and assess the comparative diagnostic value and discordance of the two devices.
Methods : The trial will recruit 142 participants with lung lesions suspected of malignancy who are eligible for an elective ENB procedure under moderate sedation. Participants will undergo ENB-guided needle aspiration and forceps biopsy in a randomized order without the use of any complementary techniques. All participants will be followed up subsequently for up to 12months to conclude the final diagnosis of the biopsied lesions. Primary outcomes include the diagnostic yield and sensitivity of each biopsy modality and the diagnostic yield of the combined modalities.
Discussion : The CONFIDENT-ENB trial will prospectively evaluate the synergistic effectiveness and comparative accuracy of ENB-guided needle aspiration and forceps biopsy in a least-invasive setting. The results are expected to improve our understanding of the optimal tool-selection strategy for ENB.
Trial registration: ClinicalTrials.gov (NCT05110131). Prospectively registered on 5 November 2021.
ko_KR
dc.description.sponsorshipThis study is supported by the Seoul National University Bundang Hospital (grant number 06-2021-0454). The funder of the study has no role in the study design, data collection, data analysis, data interpretation, or writing of the manuscript.ko_KR
dc.language.isoenko_KR
dc.publisherBMCko_KR
dc.subjectElectromagnetic navigation bronchoscopy-
dc.subjectLung neoplasms-
dc.subjectDiagnostic imaging-
dc.subjectPulmonary medicine-
dc.titleEvaluation of the synergistic impact of needle and forceps biopsy with electromagnetic navigation bronchoscopy: the CONFIDENT-ENB trial designko_KR
dc.typeArticleko_KR
dc.identifier.doi10.1186/s12890-022-02104-wko_KR
dc.citation.journaltitleBMC Pulmonary Medicine.ko_KR
dc.language.rfc3066en-
dc.rights.holderThe Author(s)-
dc.date.updated2022-08-21T03:10:53Z-
dc.citation.number1ko_KR
dc.citation.startpage319ko_KR
dc.citation.volume22ko_KR
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