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Increased pulsatility index of the basilar artery is a risk factor for neurological deterioration after stroke: a case control study

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dc.contributor.authorYoo, Il-Han-
dc.contributor.authorKim, Jeong-Min-
dc.contributor.authorHan, Su-Hyun-
dc.contributor.authorRyu, Jaiyoung-
dc.contributor.authorJung, Keun-Hwa-
dc.contributor.authorPark, Kwang-Yeol-
dc.identifier.citationClinical Hypertension, 28(1):27ko_KR
dc.description.abstractBackground : Higher pulsatility of the middle cerebral artery (MCA) is known to be associated with stroke progression. We investigated whether pulsatility index (PI) of the basilar artery (BA) can predict neurological deterioration (ND) after acute cerebral infarction.
Methods : A total of 708 consecutive patients with acute ischemic stroke who had undergone transcranial Doppler (TCD) ultrasonography were included. ND was defined as an increase in the National Institutes of Health Stroke Scale scores by two or more points after admission. The patients were categorized into quartiles according to BA PI. Multivariable logistic regression analysis was performed to examine whether BA PI is independently associated with ND.
Results : BA PI was well correlated with the right (n =474, r2 = 0.573, P <0.001) by Pearson correlation analysis although MCA PI could not be measured from right MCA (n =234, 33.05%) and left MCA (n =252, 35.59%) by TCD owing to insufficient temporal bone window. Multivariable logistic regression analysis including age, sex, cerebral atherosclerosis burden, National Institutes of Health Stroke Scale at admission, and the proportion of patients with current smoking status, hypertension, diabetes mellitus, atrial fibrillation revealed that the higher BA PI (odds ratio, 3.28; confidence interval, 1.07–10.17; P =0.038) was independently associated with ND.
Conclusions : BA PI, which would be identified regardless of temporal window, could predict ND among acute stroke patients.
dc.description.sponsorshipThe work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2017R1D1A1B03029909, NRF-2019R1F1A1059455) and by the Korean Society of Hypertension (2019). The funding has no role in design, collection, analysis, or interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication.ko_KR
dc.subjectBasilar artery-
dc.subjectTranscranial Doppler sonography-
dc.subjectNeurological deterioration-
dc.titleIncreased pulsatility index of the basilar artery is a risk factor for neurological deterioration after stroke: a case control studyko_KR
dc.citation.journaltitleClinical Hypertensionko_KR
dc.rights.holderThe Author(s)-
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