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Adenine oligomer directed synthesis of chiral gold nanoparticles

Cited 30 time in Web of Science Cited 33 time in Scopus

Cho, Nam Heon; Kim, Young Bi; Lee, Yoon Young; Im, Sang Won; Kim, Ryeong Myeong; Kim, Jeong Won; Namgung, Seok Daniel; Lee, Hye-Eun; Kim, Hyeohn; Han, Jeong Hyun; Chung, Hye Won; Lee, Yoon Ho; Han, Jeong Woo; Nam, Ki Tae

Issue Date
Nature Publishing Group
Nature Communications, Vol.13 No.1, p. 3831
Precise control of morphology and optical response of 3-dimensional chiral nanoparticles remain as a significant challenge. This work demonstrates chiral gold nanoparticle synthesis using single-stranded oligonucleotide as a chiral shape modifier. The homo-oligonucleotide composed of Adenine nucleobase specifically show a distinct chirality development with a dissymmetric factor up to g similar to 0.04 at visible wavelength, whereas other nucleobases show no development of chirality. The synthesized nanoparticle shows a counter-clockwise rotation of generated chiral arms with approximately 200 nm edge length. The molecular dynamics and density functional theory simulations reveal that Adenine shows the highest enantioselective interaction with Au(321)(R/S) facet in terms of binding orientation and affinity. This is attributed to the formation of sequence-specific intra-strand hydrogen bonding between nucleobases. We also found that different sequence programming of Adenine-and Cytosine-based oligomers result in chiral gold nanoparticles' morphological and optical change. These results extend our understanding of the biomolecule-directed synthesis of chiral gold nanoparticles to sequence programmable deoxyribonucleic acid and provides a foundation for programmable synthesis of chiral gold nanoparticles.
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