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Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels
DC Field | Value | Language |
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dc.contributor.author | Won, Ki-Bum | - |
dc.contributor.author | Lee, Byoung Kwon | - |
dc.contributor.author | Heo, Ran | - |
dc.contributor.author | Park, Hyung-Bok | - |
dc.contributor.author | Lin, Fay Y. | - |
dc.contributor.author | Hadamitzky, Martin | - |
dc.contributor.author | Kim, Yong-Jin | - |
dc.contributor.author | Sung, Ji Min | - |
dc.contributor.author | Conte, Edoardo | - |
dc.contributor.author | Andreini, Daniele | - |
dc.contributor.author | Pontone, Gianluca | - |
dc.contributor.author | Budoff, Matthew J. | - |
dc.contributor.author | Gottlieb, Ilan | - |
dc.contributor.author | Chun, Eun Ju | - |
dc.contributor.author | Cademartiri, Filippo | - |
dc.contributor.author | Maffei, Erica | - |
dc.contributor.author | Marques, Hugo | - |
dc.contributor.author | de Araújo Gonçalves, Pedro | - |
dc.contributor.author | Leipsic, Jonathon A. | - |
dc.contributor.author | Lee, Sang-Eun | - |
dc.contributor.author | Shin, Sanghoon | - |
dc.contributor.author | Choi, Jung Hyun | - |
dc.contributor.author | Virmani, Renu | - |
dc.contributor.author | Samady, Habib | - |
dc.contributor.author | Chinnaiyan, Kavitha | - |
dc.contributor.author | Berman, Daniel S. | - |
dc.contributor.author | Narula, Jagat | - |
dc.contributor.author | Bax, Jeroen J. | - |
dc.contributor.author | Min, James K. | - |
dc.contributor.author | Chang, Hyuk-Jae | - |
dc.date.accessioned | 2022-09-29T03:17:22Z | - |
dc.date.available | 2022-09-29T03:17:22Z | - |
dc.date.created | 2022-07-19 | - |
dc.date.issued | 2022-06 | - |
dc.identifier.citation | JACC: Asia, Vol.2 No.3P2, pp.311-319 | - |
dc.identifier.issn | 2772-3747 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184561 | - |
dc.description.abstract | © 2022 The AuthorsBackground: Despite a potential role of hemoglobin in atherosclerosis, data on coronary plaque volume changes (PVC) related to serum hemoglobin levels are limited. Objectives: The authors sought to evaluate coronary atherosclerotic plaque burden changes related to serum hemoglobin levels using serial coronary computed tomographic angiography (CCTA). Methods: A total of 830 subjects (age 61 ± 10 years, 51.9% male) who underwent serial CCTA were analyzed. The median interscan period was 3.2 (IQR: 2.5-4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were stratified into 4 groups based on the quartile of baseline hemoglobin levels. Annualized total PVC (mm3/year) was defined as total PVC divided by the interscan period. Results: Baseline total plaque volume (mm3) was not different among all groups (group I [lowest]: 34.1 [IQR: 0.0-127.4] vs group II: 28.8 [IQR: 0.0-123.0] vs group III: 49.9 [IQR: 5.6-135.0] vs group IV [highest]: 34.3 [IQR: 0.0-130.7]; P = 0.235). During follow-up, serum hemoglobin level changes (Δ hemoglobin; per 1 g/dL) was related to annualized total PVC (β = −0.114) in overall participants (P < 0.05). After adjusting for age, sex, traditional risk factors, baseline hemoglobin and creatinine levels, baseline total plaque volume, and the use of aspirin, beta-blocker, angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, and statin, Δ hemoglobin significantly affected annualized total PVC in only the composite of groups I and II (β = −2.401; P = 0.004). Conclusions: Serial CCTA findings suggest that Δ hemoglobin has an independent effect on coronary atherosclerosis. This effect might be influenced by baseline hemoglobin levels. (Progression of Atherosclerotic Plaque Determined by Computed Tomographic Angiography Imaging [PARADIGM]; NCT02803411) | - |
dc.language | 영어 | - |
dc.publisher | Elsevier | - |
dc.title | Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jacasi.2021.10.010 | - |
dc.citation.journaltitle | JACC: Asia | - |
dc.identifier.scopusid | 2-s2.0-85132151640 | - |
dc.citation.endpage | 319 | - |
dc.citation.number | 3P2 | - |
dc.citation.startpage | 311 | - |
dc.citation.volume | 2 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Jin | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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