Publications
Detailed Information
Risk factors for overcorrection of severe hyponatremia: a post hoc analysis of the SALSA trial
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Huijin | - |
dc.contributor.author | Yoon, Songuk | - |
dc.contributor.author | Kim, Eun Jung | - |
dc.contributor.author | Seo, Jang Won | - |
dc.contributor.author | Koo, Ja-Ryong | - |
dc.contributor.author | Oh, Yun Kyu | - |
dc.contributor.author | Jo, You Hwan | - |
dc.contributor.author | Kim, Sejoong | - |
dc.contributor.author | Baek, Seon Ha | - |
dc.date.accessioned | 2022-09-29T03:18:33Z | - |
dc.date.available | 2022-09-29T03:18:33Z | - |
dc.date.created | 2022-07-13 | - |
dc.date.created | 2022-07-13 | - |
dc.date.created | 2022-07-13 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.citation | Kidney Research and Clinical Practice, Vol.41 No.3, pp.298-309 | - |
dc.identifier.issn | 2211-9132 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184654 | - |
dc.description.abstract | © 2022 by The Korean Society of Nephrology.Background: Hyponatremia overcorrection can result in irreversible neurologic impairment such as osmotic demyelination syndrome. Few prospective studies have identified patients undergoing hypertonic saline treatment with a high risk of hyponatremia overcorrec-tion. Methods: We conducted a post hoc analysis of a multicenter, prospective randomized controlled study, the SALSA trial, in 178 patients aged above 18 years with symptomatic hyponatremia (mean age, 73.1 years; mean serum sodium level, 118.2 mEq/L). Over-correction was defined as an increase in serum sodium levels by >12 or 18 mEq/L within 24 or 48 hours, respectively. Results: Among the 178 patients, 37 experienced hyponatremia overcorrection (20.8%), which was independently associated with initial serum sodium level (≤110, 110–115, 115–120, and 120–125 mEq/L with 7, 4, 2, and 0 points, respectively), chronic alcoholism (7 points), severe symptoms of hyponatremia (3 points), and initial potassium level (<3.0 mEq/L, 3 points). The NASK (hypoNa-tremia, Alcoholism, Severe symptoms, and hypoKalemia) score was derived from four risk factors for hyponatremia overcorrection and was significantly associated with overcorrection (odds ratio, 1.41; 95% confidence interval, 1.24–1.61; p < 0.01) with good discrimi-nation (area under the receiver-operating characteristic [AUROC] curve, 0.76; 95% CI, 0.66–0.85; p < 0.01). The AUROC curve of the NASK score was statistically better compared with those of each risk factor. Conclusion: In treating patients with symptomatic hyponatremia, individuals with high hyponatremia overcorrection risks were pre-dictable using a novel risk score summarizing baseline information. | - |
dc.language | 영어 | - |
dc.publisher | 대한신장학회 | - |
dc.title | Risk factors for overcorrection of severe hyponatremia: a post hoc analysis of the SALSA trial | - |
dc.type | Article | - |
dc.identifier.doi | 10.23876/j.krcp.21.180 | - |
dc.citation.journaltitle | Kidney Research and Clinical Practice | - |
dc.identifier.wosid | 000880075100005 | - |
dc.identifier.scopusid | 2-s2.0-85131813011 | - |
dc.citation.endpage | 309 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 298 | - |
dc.citation.volume | 41 | - |
dc.identifier.kciid | ART002846797 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Oh, Yun Kyu | - |
dc.contributor.affiliatedAuthor | Jo, You Hwan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | RAPID CORRECTION | - |
dc.subject.keywordPlus | HYPERTONIC SALINE | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordAuthor | Hyponatremia | - |
dc.subject.keywordAuthor | Novel risk score | - |
dc.subject.keywordAuthor | Overcorrection | - |
dc.subject.keywordAuthor | Prediction | - |
dc.subject.keywordAuthor | Risk factors | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.