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Left Ventricular Diastolic Dysfunction and Progression of Chronic Kidney Disease: Analysis of KNOW-CKD Data
DC Field | Value | Language |
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dc.contributor.author | Kang, Eunjeong | - |
dc.contributor.author | Lee, Sung Woo | - |
dc.contributor.author | Ryu, Hyunjin | - |
dc.contributor.author | Kang, Minjung | - |
dc.contributor.author | Kim, Seonmi | - |
dc.contributor.author | Park, Sue K. | - |
dc.contributor.author | Jung, Ji Yong | - |
dc.contributor.author | Lee, Kyu-Beck | - |
dc.contributor.author | Han, Seung Hyeok | - |
dc.contributor.author | Ahn, Curie | - |
dc.contributor.author | Oh, Kook-Hwan | - |
dc.date.accessioned | 2022-09-29T03:18:52Z | - |
dc.date.available | 2022-09-29T03:18:52Z | - |
dc.date.created | 2022-07-11 | - |
dc.date.issued | 2022-07 | - |
dc.identifier.citation | Journal of the American Heart Association, Vol.11 No.13, p. e025554 | - |
dc.identifier.issn | 2047-9980 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184679 | - |
dc.description.abstract | Background Few studies have examined the association between the early diastolic mitral inflow velocity/early diastolic mitral annulus velocity ratio (E/e') and chronic kidney disease progression. Methods and Results We reviewed data from 2238 patients with nondialysis chronic kidney disease from the KNOW-CKD (Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease); data from 163 patients were excluded because of missing content. A >50% decrease in estimated glomerular filtration rate from baseline, doubling of serum creatinine, or dialysis initiation and/or kidney transplantation were considered renal events. At baseline, median (interquartile range) ejection fraction and E/e' were 64.0% (60.0%-68.0%) and 9.1 (7.4-11.9), respectively. Proportions of ejection fraction <50% and E/e' >= 15 were 1.3% and 9.6%, respectively. More than one quarter of patients (27.2%) had an estimated glomerular filtration rate <30 mL/min per 1.73 m(2). During the mean 59.1-month follow-up period, 724 patients (34.9%) experienced renal events. In multivariable Cox proportional hazard regression analysis, the hazard ratio with 95% CI per 1-unit increase in E/e' was 1.027 (1.005-1.050; P=0.016). Penalized spline curve analysis yielded a suggested threshold of E/e' for renal events of 12; in our data set, the proportion of E/e' >= 12 was 4.1%. Conclusions Increased E/e' was associated with an increased hazard of renal events, suggesting that diastolic heart dysfunction is a novel risk factor for chronic kidney disease progression. | - |
dc.language | 영어 | - |
dc.publisher | Wiley-Blackwell | - |
dc.title | Left Ventricular Diastolic Dysfunction and Progression of Chronic Kidney Disease: Analysis of KNOW-CKD Data | - |
dc.type | Article | - |
dc.identifier.doi | 10.1161/JAHA.122.025554 | - |
dc.citation.journaltitle | Journal of the American Heart Association | - |
dc.identifier.wosid | 000821048200025 | - |
dc.identifier.scopusid | 2-s2.0-85133896683 | - |
dc.citation.number | 13 | - |
dc.citation.startpage | e025554 | - |
dc.citation.volume | 11 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Park, Sue K. | - |
dc.contributor.affiliatedAuthor | Oh, Kook-Hwan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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