Publications
Detailed Information
Noninvasive assessment of foot perfusion in cholesterol-fed rabbits using dynamic volume perfusion CT with an upslope method
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Min, Hooney Daniel | - |
dc.contributor.author | Hur, Saebeom | - |
dc.contributor.author | Lee, Jae Hwan | - |
dc.contributor.author | Yoon, Chang Jin | - |
dc.contributor.author | Choi, Won Seok | - |
dc.contributor.author | Lee, Seunghyun | - |
dc.date.accessioned | 2022-09-29T03:18:58Z | - |
dc.date.available | 2022-09-29T03:18:58Z | - |
dc.date.created | 2022-06-20 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.citation | Scientific Reports, Vol.12 No.1, p. 8894 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184686 | - |
dc.description.abstract | To evaluate the feasibility of dynamic foot volume CT with the upslope method and to demonstrate macrovascular reactivity and microvascular perfusion during cuff-induced reactive hyperemia state in cholesterol-fed rabbits. 30 New Zealand male rabbits were divided into 2 groups: dietary hypercholesterolemia (n = 10) and normal diet control (n = 20). To measure for macrovascular reactivity, perfusion parameters of the left posterior tibial artery was measured at baseline and at reactive hyperemia state. For the evaluation of microvascular perfusion, color-coded perfusion map of the plantar dermis was generated for perfusion CT scan by an in-house developed dedicated analysis software based on upslope method. Dermal perfusion values were measured and analyzed before and after cuff-induced reactive hyperemia. Foot dynamic volume CT with the upslope method demonstrated significant impairment of both macrovascular reactivity and microvascular perfusion in cholesterol-fed rabbits without significant macrovascular lesions during cuff-induced reactive hyperemia (CRH) state. Arterial time-to-peak of cholesterol-fed rabbits failed to show acceleration while chow-fed rabbits showed significant decrease in time. Microvascular perfusion calculated by perfusion value (P < 0.01) and perfusion ratio (P = .014) showed decreased microvascular perfusion in cholesterol-fed rabbits compared to chow-fed rabbits during CRH state. Post-CT pathologic examination revealed decreased endothelial cell density in cholesterol-fed rabbits (P < 0.001). Foot perfusion CT using upslope method provides perfusion parameters for large arteries and a perfusion map of the foot during cuff-induced reactive hyperemia in cholesterol-fed rabbits. It may be a useful tool to assess microvascular reactivity in patients with peripheral artery disease but no apparent macrovascular lesions. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Noninvasive assessment of foot perfusion in cholesterol-fed rabbits using dynamic volume perfusion CT with an upslope method | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-022-12756-7 | - |
dc.citation.journaltitle | Scientific Reports | - |
dc.identifier.wosid | 000802776400104 | - |
dc.identifier.scopusid | 2-s2.0-85130788889 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 8894 | - |
dc.citation.volume | 12 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Hur, Saebeom | - |
dc.contributor.affiliatedAuthor | Yoon, Chang Jin | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.