Publications
Detailed Information
Clinical Characteristics of COVID-19: Use of Steroids in Mostly Unvaccinated COVID-19 Patients Before the Omicron Variant
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Sang-Min | - |
dc.contributor.author | Ham, Sin Young | - |
dc.contributor.author | Suh, Hyeon Jeong | - |
dc.contributor.author | Lee, Eunyoung | - |
dc.contributor.author | Park, Sang-Won | - |
dc.date.accessioned | 2022-09-29T03:19:12Z | - |
dc.date.available | 2022-09-29T03:19:12Z | - |
dc.date.created | 2022-08-12 | - |
dc.date.issued | 2022-07 | - |
dc.identifier.citation | Journal of Korean Medical Science, Vol.37 No.29, p. e228 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184703 | - |
dc.description.abstract | Background: Glucocorticoids are one of the current standard agents for moderate to severe coronavirus disease 2019 (COVID-19) treatment based on the RECOVERY trial. Data on the real clinical application of steroids for COVID-19 are scarce and will help guide the optimal use of steroids. We described the current prescription pattern of steroids for COVID-19 and investigated the factors related to specific practices. Methods: All adults aged >= 19 years who were diagnosed with COVID-19 by real-time reverse transcription-polymerase chain reaction and admitted to one of 3 study hospitals from 8 December 2020 to 30 June 2021 were enrolled. Demographic and clinical data, including medications and oxygen therapy, were retrospectively collected from electronic medical records. The severity of comorbidities and COVID-19 were measured. The subjects were divided into steroid and nonsteroid groups, and the steroid group was then subdivided into standard and higher/longer groups. Results: Among a total of 805 patients, 217 (27.0%) were treated with steroids. The steroid group showed a higher rate of oxygen therapy (81.1% vs. 2.7%), more concomitant use of remdesivir (77.4% vs. 1.4%) or antibiotics (79.3% vs. 4.3%), and a higher proportion of high risk according to National Early Warning Score-2 score (30.0% vs. 0.9%) or severe risk according to National Institute of Allergy and Infectious Disease Ordinal Scale score (81.1% vs. 2.7%) than the nonsteroid group. The mortality of the steroid group was 4.6%. In the steroid group, 82.5% received a standard or lower dose of steroids within ten days, and 17.5% (38/217) received a higher or longer dose of steroids. Multivariate analysis showed that initial lymphopenia (adjusted odds ratio [aOR], 0.94; 95% confidence interval [CI], 0.89-0.99) and high level of lactate dehydrogenase (LDH) (aOR, 1.00; 95% CI, 1.00-1.01) were independent risk factors for higher doses or longer steroid use. Conclusion: The dose and duration of steroids were in line with current guidelines in 82.5% of COVID-19 patients, but the outliers may need tailored therapy according to surrogate markers, such as initial lymphopenia or high level of LDH. | - |
dc.language | 영어 | - |
dc.publisher | 대한의학회 | - |
dc.title | Clinical Characteristics of COVID-19: Use of Steroids in Mostly Unvaccinated COVID-19 Patients Before the Omicron Variant | - |
dc.type | Article | - |
dc.identifier.doi | 10.3346/jkms.2022.37.e228 | - |
dc.citation.journaltitle | Journal of Korean Medical Science | - |
dc.identifier.wosid | 000831690100004 | - |
dc.identifier.scopusid | 2-s2.0-85135045975 | - |
dc.citation.number | 29 | - |
dc.citation.startpage | e228 | - |
dc.citation.volume | 37 | - |
dc.identifier.kciid | ART002862247 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Eunyoung | - |
dc.contributor.affiliatedAuthor | Park, Sang-Won | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.