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Clinical Performance of Rapid and Point-of-Care Antigen Tests for SARS-CoV-2 Variants of Concern: A Living Systematic Review and Meta-Analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jimin | - |
dc.contributor.author | Sung, Heungsup | - |
dc.contributor.author | Lee, Hyukmin | - |
dc.contributor.author | Kim, Jae-Seok | - |
dc.contributor.author | Shin, Sue | - |
dc.contributor.author | Jeong, Seri | - |
dc.contributor.author | Choi, Miyoung | - |
dc.contributor.author | Lee, Hyeon-Jeong | - |
dc.date.accessioned | 2022-09-29T03:19:23Z | - |
dc.date.available | 2022-09-29T03:19:23Z | - |
dc.date.created | 2022-07-27 | - |
dc.date.issued | 2022-07 | - |
dc.identifier.citation | Viruses, Vol.14 No.7, p. 1479 | - |
dc.identifier.issn | 1999-4915 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184716 | - |
dc.description.abstract | © 2022 by the authors. Licensee MDPI, Basel, Switzerland.Rapid antigen tests (RATs) for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are widely used in the Coronavirus disease 2019 (COVID-19) pandemic caused by diverse variants. Information on the real-world performance of RATs for variants is urgently needed for decision makers. Systematic searches of the available literature and updates were conducted in PubMed, Ovid-MEDLINE, Ovid-EMBASE, CENTRAL, and KMBASE for articles evaluating the accuracy of instrument-free RATs for variants up until 14 March 2022. A bivariate random effects model was utilized to calculate pooled diagnostic values in comparison with real-time reverse transcription-polymerase chain reaction as the reference test. A total of 7562 samples from six studies were available for the meta-analysis. The overall pooled sensitivity and specificity of RATs for variants were 69.7% (95% confidence interval [CI] = 62.5% to 76.1%) and 100.0% (95% CI = 98.8% to 100.0%), respectively. When an additional 2179 samples from seven studies reporting sensitivities only were assessed, the pooled sensitivity dropped to 50.0% (95% CI = 44.0% to 55.0%). These findings suggest reassessment and monitoring of the diagnostic utility of RATs for variants, especially for the sensitivity aspect, to facilitate appropriate diagnosis and management of COVID-19 patients. | - |
dc.language | 영어 | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Clinical Performance of Rapid and Point-of-Care Antigen Tests for SARS-CoV-2 Variants of Concern: A Living Systematic Review and Meta-Analysis | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/v14071479 | - |
dc.citation.journaltitle | Viruses | - |
dc.identifier.wosid | 000831651000001 | - |
dc.identifier.scopusid | 2-s2.0-85133825997 | - |
dc.citation.number | 7 | - |
dc.citation.startpage | 1479 | - |
dc.citation.volume | 14 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Shin, Sue | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
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