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Imaging diagnosis of hepatocellular carcinoma: Future directions with special emphasis on hepatobiliary magnetic resonance imaging and contrast-enhanced ultrasound

Cited 16 time in Web of Science Cited 16 time in Scopus
Authors

Park, Junghoan; Lee, Jeong Min; Kim, Tae-Hyung; Yoon, Jeong Hee

Issue Date
2022-07
Publisher
대한간학회
Citation
Clinical and Molecular Hepatology, Vol.28 No.3, pp.362-379
Abstract
© 2022 by Korean Association for the Study of the Liver.Hepatocellular carcinoma (HCC) is a unique cancer entity that can be noninvasively diagnosed using imaging modalities without pathologic confirmation. In 2018, several major guidelines for HCC were updated to include hepatobiliary contrast agent magnetic resonance imaging (HBA-MRI) and contrast-enhanced ultrasound (CEUS) as major imaging modalities for HCC diagnosis. HBA-MRI enables the achievement of high sensitivity in HCC detection using the hepatobiliary phase (HBP). CEUS is another imaging modality with real-time imaging capability, and it is reported to be useful as a second-line modality to increase sensitivity without losing specificity for HCC diagnosis. However, until now, there is an unsolved discrepancy among guidelines on whether to accept HBP hypointensity as a definite diagnostic criterion for HCC or include CEUS in the diagnostic algorithm for HCC diagnosis. Furthermore, there is variability in terminology and inconsistencies in the definition of imaging findings among guidelines; therefore, there is an unmet need for the development of a standardized lexicon. In this article, we review the performance and limitations of HBAMRI and CEUS after guideline updates in 2018 and briefly introduce some future aspects of imaging-based HCC diagnosis.
ISSN
2287-2728
URI
https://hdl.handle.net/10371/184717
DOI
https://doi.org/10.3350/cmh.2021.0361
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