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Transcriptome analysis of SerpinB2-deficient breast tumors provides insight into deciphering SerpinB2-mediated roles in breast cancer progression
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Piao, Yin Ji | - |
dc.contributor.author | Kim, Hoe Suk | - |
dc.contributor.author | Han, Wonshik | - |
dc.contributor.author | Moon, Woo Kyung | - |
dc.date.accessioned | 2022-09-29T03:19:38Z | - |
dc.date.available | 2022-09-29T03:19:38Z | - |
dc.date.created | 2022-07-12 | - |
dc.date.issued | 2022-06 | - |
dc.identifier.citation | BMC Genomics, Vol.23 No.1, p. 479 | - |
dc.identifier.issn | 1471-2164 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184736 | - |
dc.description.abstract | Background SerpinB2 is highly expressed in immune and tumor cells and is involved in multiple biological functions, including cell survival and remodeling for disease progression. This study prepared SerpinB2-deficient mice and analyzed the differentially expressed genes (DEGs) to determine if loss of this protein delays mammary tumor progression. Results A total of 305 DEGs (75 upregulated and 230 downregulated; > 1.5-fold difference, P < 0.05) were identified in SB2-/-;PyMT tumors compared with PyMT tumors. The DEGs were mainly involved in immune and inflammatory responses related to T cell differentiation, IFN-gamma production, and lymphocyte chemotaxis based on 61 enriched GO terms, hierarchical clustering, KEGG pathways, and a functionally grouped annotation network. The significantly changed DEGs (Anxa3, Ccl17, Cxcl13, Cxcr3, IFN-gamma, Nr4a1, and Sema3a) annotated with at least two GO categories in SB2-/-;PyMT tumors was validated by qRT-PCR. Conclusions SerpinB2 deficiency alters the expression of multiple genes in mammary tumors, which might cause a delay in PyMT-induced mammary tumor progression. | - |
dc.language | 영어 | - |
dc.publisher | BioMed Central | - |
dc.title | Transcriptome analysis of SerpinB2-deficient breast tumors provides insight into deciphering SerpinB2-mediated roles in breast cancer progression | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s12864-022-08704-4 | - |
dc.citation.journaltitle | BMC Genomics | - |
dc.identifier.wosid | 000818785400002 | - |
dc.identifier.scopusid | 2-s2.0-85133010510 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 479 | - |
dc.citation.volume | 23 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Han, Wonshik | - |
dc.contributor.affiliatedAuthor | Moon, Woo Kyung | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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