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Effects of ischemic conditioning on head and neck free flap oxygenation: a randomized controlled trial
DC Field | Value | Language |
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dc.contributor.author | Min, Se-Hee | - |
dc.contributor.author | Choe, Suk Hyung | - |
dc.contributor.author | Kim, Won Shik | - |
dc.contributor.author | Ahn, Soon-Hyun | - |
dc.contributor.author | Cho, Youn Joung | - |
dc.date.accessioned | 2022-09-29T03:19:51Z | - |
dc.date.available | 2022-09-29T03:19:51Z | - |
dc.date.created | 2022-07-21 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.citation | Scientific Reports, Vol.12 No.1, p. 8130 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184752 | - |
dc.description.abstract | Flap failure after microvascular reconstructive surgery is a rare but devastating complication caused by reperfusion injury and tissue hypoperfusion. Remote ischemic conditioning (RIC) provides protection against ischemia/reperfusion injury and reduces tissue infarction. We hypothesized that RIC would enhance flap oxygenation and exert organ-protective effects during head and neck free flap reconstructive surgery. Adult patients undergoing free flap transfer surgery for head and neck cancer were randomized to receive either RIC or sham-RIC during surgery. RIC consisted of four cycles of 5-min ischemia and 5-min reperfusion applied to the upper or lower extremity. The primary endpoint, tissue oxygen saturation of the flap, was measured by near-infrared spectroscopy on the first postoperative day. Organ-protective effects of RIC were evaluated with infarct size of rat hearts perfused with plasma dialysate from patients received RIC or sham-RIC. Between April 2018 and July 2019, 50 patients were randomized (each n = 25) and 46 were analyzed in the RIC (n = 23) or sham-RIC (n = 23) groups. Tissue oxygen saturation of the flap was similar between the groups (85 +/- 12% vs 83 +/- 9% in the RIC vs sham-RIC groups; P = 0.471). Myocardial infarct size after treatment of plasma dialysate was significantly reduced in the RIC group (44 +/- 7% to 26 +/- 6%; P = 0.018) compared to the sham-RIC group (42 +/- 6% to 37 +/- 7%; P = 0.388). RIC did not improve tissue oxygenation of the transferred free flap in head and neck cancer reconstructive surgery. However, there was evidence of organ-protective effects of RIC in experimental models. Trial registration: Registry number of ClinicalTrials.gov: NCT03474952. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Effects of ischemic conditioning on head and neck free flap oxygenation: a randomized controlled trial | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-022-12374-3 | - |
dc.citation.journaltitle | Scientific Reports | - |
dc.identifier.wosid | 000815482800086 | - |
dc.identifier.scopusid | 2-s2.0-85130111375 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 8130 | - |
dc.citation.volume | 12 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Ahn, Soon-Hyun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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