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Melatonin reduces the endoplasmic reticulum stress and polyubiquitinated protein accumulation induced by repeated anesthesia exposure in Caenorhabditis elegans
DC Field | Value | Language |
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dc.contributor.author | Shin, Hyun-Jung | - |
dc.contributor.author | Koo, Bon-Wook | - |
dc.contributor.author | Yoon, Jiwon | - |
dc.contributor.author | Kim, Heeyeon | - |
dc.contributor.author | Do, Sang-Hwan | - |
dc.contributor.author | Na, Hyo-Seok | - |
dc.date.accessioned | 2022-09-29T03:20:05Z | - |
dc.date.available | 2022-09-29T03:20:05Z | - |
dc.date.created | 2022-05-06 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.citation | Scientific Reports, Vol.12 No.1, p. 5783 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184770 | - |
dc.description.abstract | Endoplasmic reticulum (ER) stress has been linked to anesthesia-induced neurotoxicity, but melatonin seems to play a protective role against ER stress. Synchronized Caenorhabditis elegans were exposed to isoflurane during the developmental period; melatonin treatment was used to evaluate its role in preventing the defective unfolded protein response (UPR) and ER-associated protein degradation (ERAD). The induced expression of hsp-4::GFP by isoflurane was attenuated in the isoflurane-melatonin group. Isoflurane upregulated the expression of ire-1, whereas melatonin did not induce ire-1 expression in C. elegans even after isoflurane exposure. With luzindole treatment, the effect of melatonin on the level of ire-1 was significantly attenuated. The reduced expression of sel-1, sel-11, cdc-48.1, and cdc-48.2 due to isoflurane was restored by melatonin, although not up to the level of the control group. The amount of polyubiquitinated proteins was increased in the isoflurane group; however, melatonin suppressed its accumulation, which was significantly inhibited by a proteasome inhibitor, MG132. The chemotaxis index of the isoflurane-melatonin group was improved compared with the isoflurane group. Melatonin may be a potential preventive molecule against defective UPR and ERAD caused by repeated anesthesia exposure. The ire-1 branch of the UPR and ERAD pathways can be the target of melatonin to reduce anesthesia-induced ER stress. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Melatonin reduces the endoplasmic reticulum stress and polyubiquitinated protein accumulation induced by repeated anesthesia exposure in Caenorhabditis elegans | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-022-09853-y | - |
dc.citation.journaltitle | Scientific Reports | - |
dc.identifier.wosid | 000780164200106 | - |
dc.identifier.scopusid | 2-s2.0-85127661361 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 5783 | - |
dc.citation.volume | 12 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Do, Sang-Hwan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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