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Small-molecule modulators of protein-RNA interactions
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Byun, Wan Gi | - |
dc.contributor.author | Lim, Donghyun | - |
dc.contributor.author | Park, Seung Bum | - |
dc.date.accessioned | 2022-09-30T05:49:51Z | - |
dc.date.available | 2022-09-30T05:49:51Z | - |
dc.date.created | 2022-06-16 | - |
dc.date.issued | 2022-06 | - |
dc.identifier.citation | Current Opinion in Chemical Biology, Vol.68, p. 102149 | - |
dc.identifier.issn | 1367-5931 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184826 | - |
dc.description.abstract | Protein-RNA interactions (PRIs) play crucial roles in diverse cellular pathways, from transcription to liquid-liquid phase separation, and its dysregulation is associated with a wide range of human disorders. Therefore, there is great emphasis on discovering small-molecule modulators that target unexplored PRIs by developing robust PRI assays. In particular, targeting PRIs could offer innovative solutions to expand the druggable genome, as only a small portion of protein-coding genes are currently targeted by drugs. This review describes the therapeutic potential of targeting PRIs using small molecules, biochemical and cell-based experimental tools for observing PRIs, and several PRI modulators. We also highlight emerging technologies and the challenges in developing PRI modulators. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Small-molecule modulators of protein-RNA interactions | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.cbpa.2022.102149 | - |
dc.citation.journaltitle | Current Opinion in Chemical Biology | - |
dc.identifier.wosid | 000801972300001 | - |
dc.identifier.scopusid | 2-s2.0-85129623315 | - |
dc.citation.startpage | 102149 | - |
dc.citation.volume | 68 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Park, Seung Bum | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
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