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Small-molecule modulators of protein-RNA interactions

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dc.contributor.authorByun, Wan Gi-
dc.contributor.authorLim, Donghyun-
dc.contributor.authorPark, Seung Bum-
dc.date.accessioned2022-09-30T05:49:51Z-
dc.date.available2022-09-30T05:49:51Z-
dc.date.created2022-06-16-
dc.date.issued2022-06-
dc.identifier.citationCurrent Opinion in Chemical Biology, Vol.68, p. 102149-
dc.identifier.issn1367-5931-
dc.identifier.urihttps://hdl.handle.net/10371/184826-
dc.description.abstractProtein-RNA interactions (PRIs) play crucial roles in diverse cellular pathways, from transcription to liquid-liquid phase separation, and its dysregulation is associated with a wide range of human disorders. Therefore, there is great emphasis on discovering small-molecule modulators that target unexplored PRIs by developing robust PRI assays. In particular, targeting PRIs could offer innovative solutions to expand the druggable genome, as only a small portion of protein-coding genes are currently targeted by drugs. This review describes the therapeutic potential of targeting PRIs using small molecules, biochemical and cell-based experimental tools for observing PRIs, and several PRI modulators. We also highlight emerging technologies and the challenges in developing PRI modulators.-
dc.language영어-
dc.publisherElsevier BV-
dc.titleSmall-molecule modulators of protein-RNA interactions-
dc.typeArticle-
dc.identifier.doi10.1016/j.cbpa.2022.102149-
dc.citation.journaltitleCurrent Opinion in Chemical Biology-
dc.identifier.wosid000801972300001-
dc.identifier.scopusid2-s2.0-85129623315-
dc.citation.startpage102149-
dc.citation.volume68-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorPark, Seung Bum-
dc.type.docTypeReview-
dc.description.journalClass1-
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