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Valosin-containing protein regulates the stability of fused in sarcoma granules in cells by changing ATP concentrations
DC Field | Value | Language |
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dc.contributor.author | Yasuda, Kyota | - |
dc.contributor.author | Watanabe, Tomonobu M. | - |
dc.contributor.author | Kang, Myeong-Gyun | - |
dc.contributor.author | Seo, Jeong Kon | - |
dc.contributor.author | Rhee, Hyun-Woo | - |
dc.contributor.author | Tate, Shin-ichi | - |
dc.date.accessioned | 2022-09-30T05:49:52Z | - |
dc.date.available | 2022-09-30T05:49:52Z | - |
dc.date.created | 2022-07-13 | - |
dc.date.issued | 2022-06 | - |
dc.identifier.citation | FEBS Letters, Vol.596 No.11, pp.1412-1423 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184828 | - |
dc.description.abstract | © 2022 Federation of European Biochemical Societies.Fused in sarcoma (FUS), a DNA/RNA-binding protein, undergoes liquid-liquid phase separation to form granules in cells. Aberrant FUS granulation is associated with neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal lobar degeneration. We found that FUS granules contain a multifunctional AAA ATPase, valosin-containing protein (VCP), which is known as a key regulator of protein degradation. FUS granule stability depends on ATP concentrations in cells. VCP ATPase changes the FUS granule stability time-dependently by consuming ATP to reduce its concentrations in the granules: VCPs in de novo FUS granules stabilize the granules, while long-lasting VCP colocalization destabilizes the granules. The proteolysis-promoting function of VCP may subsequently dissolve the unstabilized granules. We propose that VCP colocalized to the FUS granules acts as a timer to limit the residence time of the granules in cells. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Valosin-containing protein regulates the stability of fused in sarcoma granules in cells by changing ATP concentrations | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/1873-3468.14353 | - |
dc.citation.journaltitle | FEBS Letters | - |
dc.identifier.wosid | 000786547400001 | - |
dc.identifier.scopusid | 2-s2.0-85128857676 | - |
dc.citation.endpage | 1423 | - |
dc.citation.number | 11 | - |
dc.citation.startpage | 1412 | - |
dc.citation.volume | 596 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Rhee, Hyun-Woo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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