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Antitumor Activity of Rutaecarpine in Human Colorectal Cancer Cells by Suppression of Wnt/β-Catenin Signaling : Antitumor Activity of Rutaecarpine in Human Colorectal Cancer Cells by Suppression of Wnt/beta-Catenin Signaling
DC Field | Value | Language |
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dc.contributor.author | Byun, Woong Sub | - |
dc.contributor.author | Bae, Eun Seo | - |
dc.contributor.author | Kim, Won Kyung | - |
dc.contributor.author | Lee, Sang Kook | - |
dc.date.accessioned | 2022-09-30T05:51:43Z | - |
dc.date.available | 2022-09-30T05:51:43Z | - |
dc.date.created | 2022-06-29 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.citation | Journal of Natural Products, Vol.85 No.5, pp.1407-1418 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184879 | - |
dc.description.abstract | Alkaloids derived from natural products have been traditionally used to treat various diseases, including cancers. Rutaecarpine (1), a beta-carboline-type alkaloid obtained from Evodia rutaecarpa, has been previously reported as an anti-inflammatory agent. Nonetheless, its anticancer activity and the underlying molecular mechanisms remain to be explored. In the procurement of Wnt/beta-catenin inhibitors from natural alkaloids, 1 was found to exhibit activity against the Wnt/beta-catenin-response reporter gene. Since the abnormal activation of Wnt/beta-catenin signaling is highly involved in colon carcinogenesis, the antitumor activity and molecular mechanisms of 1 were investigated in colorectal cancer (CRC) cells. The antiproliferative activity of 1 was associated with the suppression of the Wnt/beta-catenin-mediated signaling pathway and its target gene expression in human CRC cells. 1 also induced G(0)/G(1) cell cycle arrest and apoptotic cell death, and the antimigration and anti-invasion potential of 1 was confirmed through epithelial-mesenchymal transition biomarker inhibition by the regulation of Wnt signaling. The antitumor activity of 1 was supported in an Ls174T-implanted xenograft mouse model via Wnt target gene regulation. Overall, these findings suggest that targeting the Wnt/beta-catenin signaling pathway by 1 is a promising therapeutic option for the treatment of human CRC harboring beta-catenin mutation. | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Antitumor Activity of Rutaecarpine in Human Colorectal Cancer Cells by Suppression of Wnt/β-Catenin Signaling | - |
dc.title.alternative | Antitumor Activity of Rutaecarpine in Human Colorectal Cancer Cells by Suppression of Wnt/beta-Catenin Signaling | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acs.jnatprod.2c00224 | - |
dc.citation.journaltitle | Journal of Natural Products | - |
dc.identifier.wosid | 000806554600023 | - |
dc.identifier.scopusid | 2-s2.0-85130711561 | - |
dc.citation.endpage | 1418 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 1407 | - |
dc.citation.volume | 85 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Sang Kook | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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