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Chemical Constituents from the Roots and Rhizomes of Sophora tonkinensis and Their Effects on Proprotein Convertase Substilisin/Kexin Type 9 Expression
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pel, Pisey | - |
dc.contributor.author | Chae, Hee-Sung | - |
dc.contributor.author | Nhoek, Piseth | - |
dc.contributor.author | Kim, Young-Mi | - |
dc.contributor.author | An, Chae-Yeong | - |
dc.contributor.author | Yoo, Hunseung | - |
dc.contributor.author | Kang, Minseok | - |
dc.contributor.author | Kim, Hyun Woo | - |
dc.contributor.author | Choi, Young Hee | - |
dc.contributor.author | Chin, Young-Won | - |
dc.date.accessioned | 2022-09-30T05:52:11Z | - |
dc.date.available | 2022-09-30T05:52:11Z | - |
dc.date.created | 2022-07-13 | - |
dc.date.issued | 2022-06 | - |
dc.identifier.citation | ACS Omega, Vol.7 No.24, pp.20952-20958 | - |
dc.identifier.issn | 2470-1343 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184886 | - |
dc.description.abstract | This study was conducted to further investigate bioactive molecules from Sophora tonkinensis that can inhibit proprotein convertase substilisin/kexin type 9 (PCSK9) expression. After interpreting NMR spectroscopic data and MS spectral data of all isolates, a new naturally occurring compound, 6-hydroxy-vitexin-2 ''-O-rhamnoside (7), was identified along with 30 known compounds. The calculation of the gauge-including atomic orbital (GAIO) and electronic circular dichroism (ECD) proposed the absolute configuration of 17 as (2S,3R)-methyl-2-(4-hydroxybenzyl)tartrate by comparing the calculated ECD with experimental data. All isolates were tested for their inhibitory effects on PCSK9 mRNA expression. Of the tested compounds, (+)-isolariciresinol (12) inhibited PCSK9 expression via down- ation of HNF1 alpha and SREBPs. | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Chemical Constituents from the Roots and Rhizomes of Sophora tonkinensis and Their Effects on Proprotein Convertase Substilisin/Kexin Type 9 Expression | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acsomega.2c01676 | - |
dc.citation.journaltitle | ACS Omega | - |
dc.identifier.wosid | 000815335100001 | - |
dc.identifier.scopusid | 2-s2.0-85133318175 | - |
dc.citation.endpage | 20958 | - |
dc.citation.number | 24 | - |
dc.citation.startpage | 20952 | - |
dc.citation.volume | 7 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Chin, Young-Won | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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