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High Circulating Levels of Neutrophil Extracellular Traps Parameters Predicting Poor Outcome in COVID-19
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Seunghwan | - |
dc.contributor.author | Hong, Ki Ho | - |
dc.contributor.author | Gu, Ja-Yoon | - |
dc.contributor.author | In, Ji Won | - |
dc.contributor.author | Ahn, Mi Young | - |
dc.contributor.author | Kim, Hyun Kyung | - |
dc.date.accessioned | 2022-09-30T05:53:27Z | - |
dc.date.available | 2022-09-30T05:53:27Z | - |
dc.date.created | 2022-08-16 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.citation | Annals of Clinical and Laboratory Science, Vol.52 No.3, pp.374-381 | - |
dc.identifier.issn | 0091-7370 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184924 | - |
dc.description.abstract | Objective. Exploration of biomarkers to predict the severity of COVID-19 is important to reduce mortality. Upon COVID-19 infection, neutrophil extracellular traps (NET) are formed, which leads to a cytokine storm and host damage. Hence, the extent of NET formation may reflect disease progression and predict mortality in COVID-19. Methods. We measured 4 NET parameters - cell-free double stranded DNA (cell-free dsDNA), neutrophil elastase, citrullinated histone H3 (Cit-H3), and histone - DNA complex - in 188 COVID-19 patients and 20 healthy controls. Survivors (n=166) were hospitalized with or without oxygen supplementation, while non-survivors (n=22) expired during in-hospital treatment. Results. Cell-free dsDNA was significantly elevated in non-survivors in comparison with survivors and controls. The survival rate of patients with high levels of cell-free dsDNA, neutrophil elastase, and Cit-H3 was significantly lower than that of patients with low levels. These three markers significantly correlated with inflammatory markers (absolute neutrophil count and C-reactive protein). Conclusion. Since the increase in NET parameters indicates the unfavourable course of COVID-19 infection, patients predisposed to poor outcome can be rapidly managed through risk stratification by using these NET parameters. | - |
dc.language | 영어 | - |
dc.publisher | Institute for Clinical Science | - |
dc.title | High Circulating Levels of Neutrophil Extracellular Traps Parameters Predicting Poor Outcome in COVID-19 | - |
dc.type | Article | - |
dc.citation.journaltitle | Annals of Clinical and Laboratory Science | - |
dc.identifier.wosid | 000825230600004 | - |
dc.identifier.scopusid | 2-s2.0-85134083743 | - |
dc.citation.endpage | 381 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 374 | - |
dc.citation.volume | 52 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Kyung | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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