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Nonalcoholic Fatty Liver Disease and Risk of Early-Onset Vasomotor Symptoms in Lean and Overweight Premenopausal Women

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dc.contributor.authorCho, Yoosun-
dc.contributor.authorChang, Yoosoo-
dc.contributor.authorChoi, Hye Rin-
dc.contributor.authorKang, Jeonggyu-
dc.contributor.authorKwon, Ria-
dc.contributor.authorLim, Ga-Young-
dc.contributor.authorAhn, Jiin-
dc.contributor.authorKim, Kye-Hyun-
dc.contributor.authorKim, Hoon-
dc.contributor.authorHong, Yun Soo-
dc.contributor.authorZhao, Di-
dc.contributor.authorRampal, Sanjay-
dc.contributor.authorCho, Juhee-
dc.contributor.authorPark, Hyun-Young-
dc.contributor.authorGuallar, Eliseo-
dc.contributor.authorRyu, Seungho-
dc.date.accessioned2022-09-30T05:54:03Z-
dc.date.available2022-09-30T05:54:03Z-
dc.date.created2022-08-16-
dc.date.issued2022-07-
dc.identifier.citationNutrients, Vol.14 No.14-
dc.identifier.issn2072-6643-
dc.identifier.urihttps://hdl.handle.net/10371/184973-
dc.description.abstractThe role of nonalcoholic fatty liver disease (NAFLD) in vasomotor symptom (VMS) risk in premenopausal women is unknown. We examined the prevalence of early-onset VMSs according to NAFLD status in lean and overweight premenopausal women. This cross-sectional study included 4242 premenopausal Korean women (mean age 45.4 years). VMSs (hot flashes and night sweats) were assessed using the Korean version of the Menopause-Specific Quality of Life questionnaire. Hepatic steatosis was determined using liver ultrasound; lean was defined as a body mass index of <23 kg/m(2). Participants were categorized into four groups: NAFLD-free lean (reference), NAFLD-free overweight, lean NAFLD, and overweight NAFLD. Compared with the reference, the multivariable-adjusted prevalence ratios (PRs) (95% confidence intervals (CIs)) for VMSs in NAFLD-free overweight, lean NAFLD, and overweight NAFLD were 1.22 (1.06-1.41), 1.38 (1.06-1.79), and 1.49 (1.28-1.73), respectively. For moderate-to-severe VMSs, the multivariable-adjusted PRs (95% CIs) comparing NAFLD-free overweight, lean NAFLD, and overweight NAFLD to the reference were 1.38 (1.10-1.74), 1.73 (1.16-2.57), and 1.74 (1.37-2.21), respectively. NAFLD, even lean NAFLD, was significantly associated with an increased risk of prevalent early-onset VMSs and their severe forms among premenopausal women. Further studies are needed to determine the longitudinal association between NAFLD and VMS risk.-
dc.language영어-
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)-
dc.titleNonalcoholic Fatty Liver Disease and Risk of Early-Onset Vasomotor Symptoms in Lean and Overweight Premenopausal Women-
dc.typeArticle-
dc.identifier.doi10.3390/nu14142805-
dc.citation.journaltitleNutrients-
dc.identifier.wosid000831984100001-
dc.identifier.scopusid2-s2.0-85135100188-
dc.citation.number14-
dc.citation.volume14-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorKim, Hoon-
dc.type.docTypeArticle-
dc.description.journalClass1-
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