Hyperbolic disc embedding of functional human brain connectomes using resting-state fMRI

Abstract

© 2022 Massachusetts Institute of Technology.The brain presents a real complex network of modular, small-world, and hierarchical nature, which are features of non-Euclidean geometry. Using resting-state functional magnetic resonance imaging, we constructed a scale-free binary graph for each subject, using internodal time series correlation of regions of interest as a proximity measure. The resulting network could be embedded onto manifolds of various curvatures and dimensions. While maintaining the fidelity of embedding (low distortion, high mean average precision), functional brain networks were found to be best represented in the hyperbolic disc. Using the S1 /ℍ2 model, we reduced the dimension of the network into two-dimensional hyperbolic space and were able to efficiently visualize the internodal connections of the brain, preserving proximity as distances and angles on the hyperbolic discs. Each individual disc revealed relevance with its anatomic counterpart and absence of center-spaced node. Using the hyperbolic distance on the S1 /ℍ2 model, we could detect the anomaly of network in autism spectrum disorder subjects. This procedure of embedding grants us a reliable new framework for studying functional brain networks and the possibility of detecting anomalies of the network in the hyperbolic disc on an individual scale.