Publications
Detailed Information
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mahajan, Anubha | - |
dc.contributor.author | Spracklen, Cassandra N. | - |
dc.contributor.author | Zhang, Weihua | - |
dc.contributor.author | Ng, Maggie C. Y. | - |
dc.contributor.author | Petty, Lauren E. | - |
dc.contributor.author | Kitajima, Hidetoshi | - |
dc.contributor.author | Yu, Grace Z. | - |
dc.contributor.author | Rueger, Sina | - |
dc.contributor.author | Speidel, Leo | - |
dc.contributor.author | Kim, Young Jin | - |
dc.contributor.author | Horikoshi, Momoko | - |
dc.contributor.author | Mercader, Josep M. | - |
dc.contributor.author | Taliun, Daniel | - |
dc.contributor.author | Moon, Sanghoon | - |
dc.contributor.author | Kwak, Soo-Heon | - |
dc.contributor.author | Robertson, Neil R. | - |
dc.contributor.author | Rayner, Nigel W. | - |
dc.contributor.author | Loh, Marie | - |
dc.contributor.author | Kim, Bong-Jo | - |
dc.contributor.author | Chiou, Joshua | - |
dc.contributor.author | Miguel-Escalada, Irene | - |
dc.contributor.author | Parolo, Pietro della Briotta | - |
dc.contributor.author | Lin, Kuang | - |
dc.contributor.author | Bragg, Fiona | - |
dc.contributor.author | Preuss, Michael H. | - |
dc.contributor.author | Takeuchi, Fumihiko | - |
dc.contributor.author | Nano, Jana | - |
dc.contributor.author | Guo, Xiuqing | - |
dc.contributor.author | Lamri, Amel | - |
dc.contributor.author | Nakatochi, Masahiro | - |
dc.contributor.author | Scott, Robert A. | - |
dc.contributor.author | Lee, Jung-Jin | - |
dc.contributor.author | Huerta-Chagoya, Alicia | - |
dc.contributor.author | Graff, Mariaelisa | - |
dc.contributor.author | Chai, Jin-Fang | - |
dc.contributor.author | Parra, Esteban J. | - |
dc.contributor.author | Yao, Jie | - |
dc.contributor.author | Bielak, Lawrence F. | - |
dc.contributor.author | Tabara, Yasuharu | - |
dc.contributor.author | Hai, Yang | - |
dc.contributor.author | Steinthorsdottir, Valgerdur | - |
dc.contributor.author | Cook, James P. | - |
dc.contributor.author | Kals, Mart | - |
dc.contributor.author | Grarup, Niels | - |
dc.contributor.author | Schmidt, Ellen M. | - |
dc.contributor.author | Pan, Ian | - |
dc.contributor.author | Sofer, Tamar | - |
dc.contributor.author | Wuttke, Matthias | - |
dc.contributor.author | Sarnowski, Chloe | - |
dc.contributor.author | Gieger, Christian | - |
dc.contributor.author | Nousome, Darryl | - |
dc.contributor.author | Trompet, Stella | - |
dc.contributor.author | Long, Jirong | - |
dc.contributor.author | Sun, Meng | - |
dc.contributor.author | Tong, Lin | - |
dc.contributor.author | Chen, Wei-Min | - |
dc.contributor.author | Ahmad, Meraj | - |
dc.contributor.author | Noordam, Raymond | - |
dc.contributor.author | Lim, Victor J. Y. | - |
dc.contributor.author | Tam, Claudia H. T. | - |
dc.contributor.author | Joo, Yoonjung Yoonie | - |
dc.contributor.author | Chen, Chien-Hsiun | - |
dc.contributor.author | Raffield, Laura M. | - |
dc.contributor.author | Lecoeur, Cecile | - |
dc.contributor.author | Prins, Bram Peter | - |
dc.contributor.author | Nicolas, Aude | - |
dc.contributor.author | Yanek, Lisa R. | - |
dc.contributor.author | Chen, Guanjie | - |
dc.contributor.author | Jensen, Richard A. | - |
dc.contributor.author | Tajuddin, Salman | - |
dc.contributor.author | Kabagambe, Edmond K. | - |
dc.contributor.author | An, Ping | - |
dc.contributor.author | Xiang, Anny H. | - |
dc.contributor.author | Choi, Hyeok Sun | - |
dc.contributor.author | Cade, Brian E. | - |
dc.contributor.author | Tan, Jingyi | - |
dc.contributor.author | Flanagan, Jack | - |
dc.contributor.author | Abaitua, Fernando | - |
dc.contributor.author | Adair, Linda S. | - |
dc.contributor.author | Adeyemo, Adebowale | - |
dc.contributor.author | Aguilar-Salinas, Carlos A. | - |
dc.contributor.author | Akiyama, Masato | - |
dc.contributor.author | Anand, Sonia S. | - |
dc.contributor.author | Bertoni, Alain | - |
dc.contributor.author | Bian, Zheng | - |
dc.contributor.author | Bork-Jensen, Jette | - |
dc.contributor.author | Brandslund, Ivan | - |
dc.contributor.author | Brody, Jennifer A. | - |
dc.contributor.author | Brummett, Chad M. | - |
dc.contributor.author | Buchanan, Thomas A. | - |
dc.contributor.author | Canouil, Mickael | - |
dc.contributor.author | Chan, Juliana C. N. | - |
dc.contributor.author | Chang, Li-Ching | - |
dc.contributor.author | Chee, Miao-Li | - |
dc.contributor.author | Chen, Ji | - |
dc.contributor.author | Chen, Shyh-Huei | - |
dc.contributor.author | Chen, Yuan-Tsong | - |
dc.contributor.author | Chen, Zhengming | - |
dc.contributor.author | Chuang, Lee-Ming | - |
dc.contributor.author | Cushman, Mary | - |
dc.contributor.author | Das, Swapan K. | - |
dc.contributor.author | de Silva, H. Janaka | - |
dc.contributor.author | Dedoussis, George | - |
dc.contributor.author | Dimitrov, Latchezar | - |
dc.contributor.author | Doumatey, Ayo P. | - |
dc.contributor.author | Du, Shufa | - |
dc.contributor.author | Duan, Qing | - |
dc.contributor.author | Eckardt, Kai-Uwe | - |
dc.contributor.author | Emery, Leslie S. | - |
dc.contributor.author | Evans, Daniel S. | - |
dc.contributor.author | Evans, Michele K. | - |
dc.contributor.author | Fischer, Krista | - |
dc.contributor.author | Floyd, James S. | - |
dc.contributor.author | Ford, Ian | - |
dc.contributor.author | Fornage, Myriam | - |
dc.contributor.author | Franco, Oscar H. | - |
dc.contributor.author | Frayling, Timothy M. | - |
dc.contributor.author | Freedman, Barry, I | - |
dc.contributor.author | Fuchsberger, Christian | - |
dc.contributor.author | Genter, Pauline | - |
dc.contributor.author | Gerstein, Hertzel C. | - |
dc.contributor.author | Giedraitis, Vilmantas | - |
dc.contributor.author | Gonzalez-Villalpando, Clicerio | - |
dc.contributor.author | Gonzalez-Villalpando, Maria Elena | - |
dc.contributor.author | Goodarzi, Mark O. | - |
dc.contributor.author | Gordon-Larsen, Penny | - |
dc.contributor.author | Gorkin, David | - |
dc.contributor.author | Gross, Myron | - |
dc.contributor.author | Guo, Yu | - |
dc.contributor.author | Hackinger, Sophie | - |
dc.contributor.author | Han, Sohee | - |
dc.contributor.author | Hattersley, Andrew T. | - |
dc.contributor.author | Herder, Christian | - |
dc.contributor.author | Howard, Annie-Green | - |
dc.contributor.author | Hsueh, Willa | - |
dc.contributor.author | Huang, Mengna | - |
dc.contributor.author | Huang, Wei | - |
dc.contributor.author | Hung, Yi-Jen | - |
dc.contributor.author | Hwang, Mi Yeong | - |
dc.contributor.author | Hwu, Chii-Min | - |
dc.contributor.author | Ichihara, Sahoko | - |
dc.contributor.author | Ikram, Mohammad Arfan | - |
dc.contributor.author | Ingelsson, Martin | - |
dc.contributor.author | Islam, Md Tariqul | - |
dc.contributor.author | Isono, Masato | - |
dc.contributor.author | Jang, Hye-Mi | - |
dc.contributor.author | Jasmine, Farzana | - |
dc.contributor.author | Jiang, Guozhi | - |
dc.contributor.author | Jonas, Jost B. | - |
dc.contributor.author | Jorgensen, Marit E. | - |
dc.contributor.author | Jorgensen, Torben | - |
dc.contributor.author | Kamatani, Yoichiro | - |
dc.contributor.author | Kandeel, Fouad R. | - |
dc.contributor.author | Kasturiratne, Anuradhani | - |
dc.contributor.author | Katsuya, Tomohiro | - |
dc.contributor.author | Kaur, Varinderpal | - |
dc.contributor.author | Kawaguchi, Takahisa | - |
dc.contributor.author | Keaton, Jacob M. | - |
dc.contributor.author | Kho, Abel N. | - |
dc.contributor.author | Khor, Chiea-Chuen | - |
dc.contributor.author | Kibriya, Muhammad G. | - |
dc.contributor.author | Kim, Duk-Hwan | - |
dc.contributor.author | Kohara, Katsuhiko | - |
dc.contributor.author | Kriebel, Jennifer | - |
dc.contributor.author | Kronenberg, Florian | - |
dc.contributor.author | Kuusisto, Johanna | - |
dc.contributor.author | Lall, Kristi | - |
dc.contributor.author | Lange, Leslie A. | - |
dc.contributor.author | Lee, Myung-Shik | - |
dc.contributor.author | Lee, Nanette R. | - |
dc.contributor.author | Leong, Aaron | - |
dc.contributor.author | Li, Liming | - |
dc.contributor.author | Li, Yun | - |
dc.contributor.author | Li-Gao, Ruifang | - |
dc.contributor.author | Ligthart, Symen | - |
dc.contributor.author | Lindgren, Cecilia M. | - |
dc.contributor.author | Linneberg, Allan | - |
dc.contributor.author | Liu, Ching-Ti | - |
dc.contributor.author | Liu, Jianjun | - |
dc.contributor.author | Locke, Adam E. | - |
dc.contributor.author | Louie, Tin | - |
dc.contributor.author | Luan, Jian'an | - |
dc.contributor.author | Luk, Andrea O. | - |
dc.contributor.author | Luo, Xi | - |
dc.contributor.author | Lv, Jun | - |
dc.contributor.author | Lyssenko, Valeriya | - |
dc.contributor.author | Mamakou, Vasiliki | - |
dc.contributor.author | Mani, K. Radha | - |
dc.contributor.author | Meitinger, Thomas | - |
dc.contributor.author | Metspalu, Andres | - |
dc.contributor.author | Morris, Andrew D. | - |
dc.contributor.author | Nadkarni, Girish N. | - |
dc.contributor.author | Nadler, Jerry L. | - |
dc.contributor.author | Nalls, Michael A. | - |
dc.contributor.author | Nayak, Uma | - |
dc.contributor.author | Nongmaithem, Suraj S. | - |
dc.contributor.author | Ntalla, Ioanna | - |
dc.contributor.author | Okada, Yukinori | - |
dc.contributor.author | Orozco, Lorena | - |
dc.contributor.author | Patel, Sanjay R. | - |
dc.contributor.author | Pereira, Mark A. | - |
dc.contributor.author | Peters, Annette | - |
dc.contributor.author | Pirie, Fraser J. | - |
dc.contributor.author | Porneala, Bianca | - |
dc.contributor.author | Prasad, Gauri | - |
dc.contributor.author | Preissl, Sebastian | - |
dc.contributor.author | Rasmussen-Torvik, Laura J. | - |
dc.contributor.author | Reiner, Alexander P. | - |
dc.contributor.author | Roden, Michael | - |
dc.contributor.author | Rohde, Rebecca | - |
dc.contributor.author | Roll, Kathryn | - |
dc.contributor.author | Sabanayagam, Charumathi | - |
dc.contributor.author | Sander, Maike | - |
dc.contributor.author | Sandow, Kevin | - |
dc.contributor.author | Sattar, Naveed | - |
dc.contributor.author | Schonherr, Sebastian | - |
dc.contributor.author | Schurmann, Claudia | - |
dc.contributor.author | Shahriar, Mohammad | - |
dc.contributor.author | Shi, Jinxiu | - |
dc.contributor.author | Shin, Dong Mun | - |
dc.contributor.author | Shriner, Daniel | - |
dc.contributor.author | Smith, Jennifer A. | - |
dc.contributor.author | So, Wing Yee | - |
dc.contributor.author | Stancakova, Alena | - |
dc.contributor.author | Stilp, Adrienne M. | - |
dc.contributor.author | Strauch, Konstantin | - |
dc.contributor.author | Suzuki, Ken | - |
dc.contributor.author | Takahashi, Atsushi | - |
dc.contributor.author | Taylor, Kent D. | - |
dc.contributor.author | Thorand, Barbara | - |
dc.contributor.author | Thorleifsson, Gudmar | - |
dc.contributor.author | Thorsteinsdottir, Unnur | - |
dc.contributor.author | Tomlinson, Brian | - |
dc.contributor.author | Torres, Jason M. | - |
dc.contributor.author | Tsai, Fuu-Jen | - |
dc.contributor.author | Tuomilehto, Jaakko | - |
dc.contributor.author | Tusie-Luna, Teresa | - |
dc.contributor.author | Udler, Miriam S. | - |
dc.contributor.author | Valladares-Salgado, Adan | - |
dc.contributor.author | van Dam, Rob M. | - |
dc.contributor.author | van Klinken, Jan B. | - |
dc.contributor.author | Varma, Rohit | - |
dc.contributor.author | Vujkovic, Marijana | - |
dc.contributor.author | Wacher-Rodarte, Niels | - |
dc.contributor.author | Wheeler, Eleanor | - |
dc.contributor.author | Whitsel, Eric A. | - |
dc.contributor.author | Wickremasinghe, Ananda R. | - |
dc.contributor.author | van Dijk, Ko Willems | - |
dc.contributor.author | Witte, Daniel R. | - |
dc.contributor.author | Yajnik, Chittaranjan S. | - |
dc.contributor.author | Yamamoto, Ken | - |
dc.contributor.author | Yamauchi, Toshimasa | - |
dc.contributor.author | Yengo, Loic | - |
dc.contributor.author | Yoon, Kyungheon | - |
dc.contributor.author | Yu, Canqing | - |
dc.contributor.author | Yuan, Jian-Min | - |
dc.contributor.author | Yusuf, Salim | - |
dc.contributor.author | Zhang, Liang | - |
dc.contributor.author | Zheng, Wei | - |
dc.contributor.author | Raffel, Leslie J. | - |
dc.contributor.author | Igase, Michiya | - |
dc.contributor.author | Ipp, Eli | - |
dc.contributor.author | Redline, Susan | - |
dc.contributor.author | Cho, Yoon Shin | - |
dc.contributor.author | Lind, Lars | - |
dc.contributor.author | Province, Michael A. | - |
dc.contributor.author | Hanis, Craig L. | - |
dc.contributor.author | Peyser, Patricia A. | - |
dc.contributor.author | Ingelsson, Erik | - |
dc.contributor.author | Zonderman, Alan B. | - |
dc.contributor.author | Psaty, Bruce M. | - |
dc.contributor.author | Wang, Ya-Xing | - |
dc.contributor.author | Rotimi, Charles N. | - |
dc.contributor.author | Becker, Diane M. | - |
dc.contributor.author | Matsuda, Fumihiko | - |
dc.contributor.author | Liu, Yongmei | - |
dc.contributor.author | Zeggini, Eleftheria | - |
dc.contributor.author | Yokota, Mitsuhiro | - |
dc.contributor.author | Rich, Stephen S. | - |
dc.contributor.author | Kooperberg, Charles | - |
dc.contributor.author | Pankow, James S. | - |
dc.contributor.author | Engert, James C. | - |
dc.contributor.author | Chen, Yii-Der Ida | - |
dc.contributor.author | Froguel, Philippe | - |
dc.contributor.author | Wilson, James G. | - |
dc.contributor.author | Sheu, Wayne H. H. | - |
dc.contributor.author | Kardia, Sharon L. R. | - |
dc.contributor.author | Wu, Jer-Yuarn | - |
dc.contributor.author | Hayes, M. Geoffrey | - |
dc.contributor.author | Ma, Ronald C. W. | - |
dc.contributor.author | Wong, Tien-Yin | - |
dc.contributor.author | Groop, Leif | - |
dc.contributor.author | Mook-Kanamori, Dennis O. | - |
dc.contributor.author | Chandak, Giriraj R. | - |
dc.contributor.author | Collins, Francis S. | - |
dc.contributor.author | Bharadwaj, Dwaipayan | - |
dc.contributor.author | Pare, Guillaume | - |
dc.contributor.author | Sale, Michele M. | - |
dc.contributor.author | Ahsan, Habibul | - |
dc.contributor.author | Motala, Ayesha A. | - |
dc.contributor.author | Shu, Xiao-Ou | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.contributor.author | Jukema, J. Wouter | - |
dc.contributor.author | Cruz, Miguel | - |
dc.contributor.author | McKean-Cowdin, Roberta | - |
dc.contributor.author | Grallert, Harald | - |
dc.contributor.author | Cheng, Ching-Yu | - |
dc.contributor.author | Bottinger, Erwin P. | - |
dc.contributor.author | Dehghan, Abbas | - |
dc.contributor.author | Tai, E-Shyong | - |
dc.contributor.author | Dupuis, Josee | - |
dc.contributor.author | Kato, Norihiro | - |
dc.contributor.author | Laakso, Markku | - |
dc.contributor.author | Kottgen, Anna | - |
dc.contributor.author | Koh, Woon-Puay | - |
dc.contributor.author | Palmer, Colin N. A. | - |
dc.contributor.author | Liu, Simin | - |
dc.contributor.author | Abecasis, Goncalo | - |
dc.contributor.author | Kooner, Jaspal S. | - |
dc.contributor.author | Loos, Ruth J. F. | - |
dc.contributor.author | North, Kari E. | - |
dc.contributor.author | Haiman, Christopher A. | - |
dc.contributor.author | Florez, Jose C. | - |
dc.contributor.author | Saleheen, Danish | - |
dc.contributor.author | Hansen, Torben | - |
dc.contributor.author | Pedersen, Oluf | - |
dc.contributor.author | Magi, Reedik | - |
dc.contributor.author | Langenberg, Claudia | - |
dc.contributor.author | Wareham, Nicholas J. | - |
dc.contributor.author | Maeda, Shiro | - |
dc.contributor.author | Kadowaki, Takashi | - |
dc.contributor.author | Lee, Juyoung | - |
dc.contributor.author | Millwood, Iona Y. | - |
dc.contributor.author | Walters, Robin G. | - |
dc.contributor.author | Stefansson, Kari | - |
dc.contributor.author | Myers, Simon R. | - |
dc.contributor.author | Ferrer, Jorge | - |
dc.contributor.author | Gaulton, Kyle J. | - |
dc.contributor.author | Meigs, James B. | - |
dc.contributor.author | Mohlke, Karen L. | - |
dc.contributor.author | Gloyn, Anna L. | - |
dc.contributor.author | Bowden, Donald W. | - |
dc.contributor.author | Below, Jennifer E. | - |
dc.contributor.author | Chambers, John C. | - |
dc.contributor.author | Sim, Xueling | - |
dc.contributor.author | Boehnke, Michael | - |
dc.contributor.author | Rotter, Jerome, I | - |
dc.contributor.author | McCarthy, Mark, I | - |
dc.contributor.author | Morris, Andrew P. | - |
dc.date.accessioned | 2022-09-30T06:00:11Z | - |
dc.date.available | 2022-09-30T06:00:11Z | - |
dc.date.created | 2022-05-31 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.citation | Nature Genetics, Vol.54 No.5, pp.560-+ | - |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.uri | https://hdl.handle.net/10371/185126 | - |
dc.description.abstract | We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 x 10(-9)), which were delineated to 338 distinct association signals. Fine-mapping of these signals was enhanced by the increased sample size and expanded population diversity of the multi-ancestry meta-analysis, which localized 54.4% of T2D associations to a single variant with >50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying the foundations for functional investigations. Multi-ancestry genetic risk scores enhanced transferability of T2D prediction across diverse populations. Our study provides a step toward more effective clinical translation of T2D GWAS to improve global health for all, irrespective of genetic background. Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41588-022-01058-3 | - |
dc.citation.journaltitle | Nature Genetics | - |
dc.identifier.wosid | 000794118000004 | - |
dc.identifier.scopusid | 2-s2.0-85130637871 | - |
dc.citation.endpage | + | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 560 | - |
dc.citation.volume | 54 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Park, Kyong Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.