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Efficacy and Safety of Self-Titration Algorithms of Insulin Glargine 300 units/mL in Individuals with Uncontrolled Type 2 Diabetes Mellitus (The Korean TITRATION Study): A Randomized Controlled Trial
DC Field | Value | Language |
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dc.contributor.author | Bae, Jae Hyun | - |
dc.contributor.author | Ahn, Chang Ho | - |
dc.contributor.author | Yang, Ye Seul | - |
dc.contributor.author | Moon, Sun Joon | - |
dc.contributor.author | Kwak, Soo Heon | - |
dc.contributor.author | Jung, Hye Seung | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.contributor.author | Cho, Young Min | - |
dc.date.accessioned | 2022-09-30T06:00:13Z | - |
dc.date.available | 2022-09-30T06:00:13Z | - |
dc.date.created | 2022-05-12 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.citation | Diabetes and Metabolism Journal, Vol.46 No.1, pp.71-80 | - |
dc.identifier.issn | 2233-6079 | - |
dc.identifier.uri | https://hdl.handle.net/10371/185128 | - |
dc.description.abstract | Copyright © 2022 Korean Diabetes AssociationBackground: To compare the efficacy and safety of two insulin self-titration algorithms, Implementing New Strategies with Insulin Glargine for Hyperglycemia Treatment (INSIGHT) and EDITION, for insulin glargine 300 units/mL (Gla-300) in Korean individuals with uncontrolled type 2 diabetes mellitus (T2DM). Methods: In a 12-week, randomized, open-label trial, individuals with uncontrolled T2DM requiring basal insulin were randomized to either the INSIGHT (adjusted by 1 unit/day) or EDITION (adjusted by 3 units/week) algorithm to achieve a fasting self-monitoring of blood glucose (SMBG) in the range of 4.4 to 5.6 mmol/L. The primary outcome was the proportion of individuals achieving a fasting SMBG ≤5.6 mmol/L without nocturnal hypoglycemia at week 12. Results: Of 129 individuals (age, 64.1±9.5 years; 66 [51.2%] women), 65 and 64 were randomized to the INSIGHT and EDITION algorithms, respectively. The primary outcome of achievement was comparable between the two groups (24.6% vs. 23.4%, P=0.876). Compared with the EDITION group, the INSIGHT group had a greater reduction in 7-point SMBG but a similar decrease in fasting plasma glucose and glycosylated hemoglobin. The increment of total daily insulin dose was significantly higher in the INSIGHT group than in the EDITION group (between-group difference: 5.8±2.7 units/day, P=0.033). However, body weight was significantly increased only in the EDITION group (0.6±2.4 kg, P=0.038). There was no difference in the occurrence of hypoglycemia between the two groups. Patient satisfaction was significantly increased in the INSIGHT group (P=0.014). Conclusion: The self-titration of Gla-300 using the INSIGHT algorithm was effective and safe compared with that using the EDITION algorithm in Korean individuals with uncontrolled T2DM (ClinicalTrials.gov number: NCT03406663). | - |
dc.language | 영어 | - |
dc.publisher | 대한당뇨병학회 | - |
dc.title | Efficacy and Safety of Self-Titration Algorithms of Insulin Glargine 300 units/mL in Individuals with Uncontrolled Type 2 Diabetes Mellitus (The Korean TITRATION Study): A Randomized Controlled Trial | - |
dc.type | Article | - |
dc.identifier.doi | 10.4093/DMJ.2020.0274 | - |
dc.citation.journaltitle | Diabetes and Metabolism Journal | - |
dc.identifier.wosid | 000807972700007 | - |
dc.identifier.scopusid | 2-s2.0-85124434798 | - |
dc.citation.endpage | 80 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 71 | - |
dc.citation.volume | 46 | - |
dc.identifier.kciid | ART002808259 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Park, Kyong Soo | - |
dc.contributor.affiliatedAuthor | Cho, Young Min | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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