Biomarker-Determined Nonylphenol Exposure and Associated Risks in Children of Thailand, Indonesia, and Saudi Arabia

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Ringbeck, Benedikt; Bury, Daniel; Lee, Inae; Lee, Gowoon; Alakeel, Raid; Alrashed, May; Tosepu, Ramadhan; Jayadipraja, Erwin Azizi; Tantrakarnapa, Kraichat; Kliengchuay, Wissanupong; Bruning, Thomas; Choi, Kyungho; Koch, Holger M.

Issue Date
American Chemical Society
Environmental Science and Technology, Vol.56 No.14, pp.10229-10238
Nonylphenol (NP) is an endocrine disruptor and environmental contaminant. Yet, data on individual body burdens and potential health risks in humans, especially among children, are scarce. We analyzed two specific urinary NP metabolites, hydroxy-NP (OH-NP) and oxo-NP. In contrast to parent NP, OH-NP has a much higher urinary excretion fraction (Fue), and both are insusceptible to external contamination. We investigated spot urine samples from school children of Thailand (n = 104), Indonesia (n = 89), and Saudi Arabia (n = 108) and could quantify OH-NP in 100% of Indonesian and Saudi children (median concentrations: 8.12 and 8.57 mu g/L) and in 76% of Thai children (1.07 mu g/L). Median oxo-NP concentrations were 0.95, 1.10, and < 0.25 mu g/L, respectively, in line with its lower Fue. Median daily NP intakes (DIs), back-calculated from urinary OH-NP concentrations, were significantly higher in Indonesia and Saudi Arabia [0.47 and 0.36 mu g/(kg bw & BULL;d), respectively] than in Thailand [0.06 mu g/(kg bw & BULL;d)]. Maximum DIs were close to the preliminary tolerable DI of 5 mu g/(kg bw & BULL;d) from the Danish Environmental Protection Agency. Dominant sources of exposure or relevant exposure pathways could not be readily identified by questionnaire analyses and also potentially varied by region. The novel biomarkers provide long-needed support to the quantitative exposure and risk assessment of NP.
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Graduate School of Public Health (보건대학원)Dept. of Environmental Health (환경보건학과)Journal Papers (저널논문_환경보건학과)
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