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A vitronectin-derived dimeric peptide suppresses osteoclastogenesis by binding to c-Fms and inhibiting M-CSF signaling
DC Field | Value | Language |
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dc.contributor.author | Jung, Sung Youn | - |
dc.contributor.author | Min, Byung-Moo | - |
dc.date.accessioned | 2022-10-05T04:15:31Z | - |
dc.date.available | 2022-10-05T04:15:31Z | - |
dc.date.created | 2022-07-28 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.citation | Experimental Cell Research, Vol.418 No.1, p. 113252 | - |
dc.identifier.issn | 0014-4827 | - |
dc.identifier.uri | https://hdl.handle.net/10371/185400 | - |
dc.description.abstract | © 2022 Elsevier Inc.Vitronectin is an abundant multifunctional glycoprotein found in serum, the extracellular matrix, and bone, and is involved in diverse physiological processes. Here, we developed a new bioactive dimeric peptide (VnP-8-DN1 dimer) from a human vitronectin-derived motif (IDAAFTRINCQG; residues 206–217; VnP-8) via removal of an isoleucine residue at the N-terminus of VnP-8 and spontaneous air oxidation. The VnP-8-DN1 dimer potently enhanced cell attachment activity, and this activity was mediated by binding to cellular heparan sulfate proteoglycan receptors. Moreover, the VnP-8-DN1 dimer suppressed osteoclast differentiation by blocking the early stage of osteoclastogenesis induced by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL). Furthermore, the VnP-8-DN1 dimer decreased the bone-resorbing activity of osteoclasts and increased the survival of osteoclast precursor cells by decreasing the cellular level of c-Fms and reducing RANK expression. Taken together, these results demonstrate that the VnP-8-DN1 dimer inhibits the early stages of M–CSF– and RANK-induced osteoclast differentiation by binding to c-Fms and inhibiting M-CSF signaling. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | A vitronectin-derived dimeric peptide suppresses osteoclastogenesis by binding to c-Fms and inhibiting M-CSF signaling | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.yexcr.2022.113252 | - |
dc.citation.journaltitle | Experimental Cell Research | - |
dc.identifier.wosid | 000833541000002 | - |
dc.identifier.scopusid | 2-s2.0-85132321078 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 113252 | - |
dc.citation.volume | 418 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Min, Byung-Moo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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