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Synthesis of Enantiomeric ω‑Substituted Hydroxy Acids from Terminal Epoxides and Alkenes: Functional Building Blocks for Discrete and Sequence-Defined Polyesters : Synthesis of Enantiomeric omega-Substituted Hydroxy Acids from Terminal Epoxides and Alkenes: Functional Building Blocks for Discrete and Sequence-Defined Polyesters
DC Field | Value | Language |
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dc.contributor.author | Kim, Dogyun | - |
dc.contributor.author | Lee, Jeong Min | - |
dc.contributor.author | Song, Jeongeun | - |
dc.contributor.author | Lee, Seul Woo | - |
dc.contributor.author | Lee, Hong Geun | - |
dc.contributor.author | Kim, Kyoung Taek | - |
dc.date.accessioned | 2022-10-11T00:47:35Z | - |
dc.date.available | 2022-10-11T00:47:35Z | - |
dc.date.created | 2022-09-08 | - |
dc.date.issued | 2022-08 | - |
dc.identifier.citation | Macromolecules, Vol.55 No.16, pp.7193-7203 | - |
dc.identifier.issn | 0024-9297 | - |
dc.identifier.uri | https://hdl.handle.net/10371/185682 | - |
dc.description.abstract | Polyesters exhibiting a protein-like absolute atomic precision have unlimited potential for application as biomaterials and polymeric materials. Herein, we report the synthesis of enantiomeric omega-hydroxy acids (OHAs) from terminal epoxides and alkenes as starting materials. Our synthetic strategy allows the synthesis of a library of OHAs with a well-defined atomic composition (carbon number), stereochemical configuration, and substituent chemistry. These monomers can serve as building blocks for the preparation of discrete and sequence-defined polyesters, wherein various functional groups can be introduced at specific locations via the cross-convergent method. We demonstrated that the specific locations of the reactive functional groups of the sequence-defined polyester could be utilized to form a concentrically cyclic polymer upon cyclization. Our results provide a facile platform for engineering polyesters with the structural sophistication exhibited only by biopolymers, such as proteins and nucleic acids. | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Synthesis of Enantiomeric ω‑Substituted Hydroxy Acids from Terminal Epoxides and Alkenes: Functional Building Blocks for Discrete and Sequence-Defined Polyesters | - |
dc.title.alternative | Synthesis of Enantiomeric omega-Substituted Hydroxy Acids from Terminal Epoxides and Alkenes: Functional Building Blocks for Discrete and Sequence-Defined Polyesters | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acs.macromol.2c01248 | - |
dc.citation.journaltitle | Macromolecules | - |
dc.identifier.wosid | 000835994300001 | - |
dc.identifier.scopusid | 2-s2.0-85136057782 | - |
dc.citation.endpage | 7203 | - |
dc.citation.number | 16 | - |
dc.citation.startpage | 7193 | - |
dc.citation.volume | 55 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Hong Geun | - |
dc.contributor.affiliatedAuthor | Kim, Kyoung Taek | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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