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Symmetry-Adapted Synthesis of Dicopper Oxidases with Divergent Dioxygen Reactivity
DC Field | Value | Language |
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dc.contributor.author | Jung, Se-Min | - |
dc.contributor.author | Yang, Minwoo | - |
dc.contributor.author | Song, Woon Ju | - |
dc.date.accessioned | 2022-10-11T00:47:35Z | - |
dc.date.available | 2022-10-11T00:47:35Z | - |
dc.date.created | 2022-09-02 | - |
dc.date.created | 2022-09-02 | - |
dc.date.issued | 2022-08 | - |
dc.identifier.citation | Inorganic Chemistry, Vol.61 No.31, pp.12433-12441 | - |
dc.identifier.issn | 0020-1669 | - |
dc.identifier.uri | https://hdl.handle.net/10371/185683 | - |
dc.description.abstract | Artificial metalloenzymes have fed our understanding of how inorganic reactivities emerge, evolve, and diversify in protein environments. Herein, we created dinuclear copper oxidases by genetically encoding a metal-ligating unnatural amino acid (bpy-Ala) per protomer in the vicinity of the innate C2 rotational axis of a homo-oligomeric protein. The inherent protein symmetry allows the precise multiplication and placement of two Cu(bpy) species. Depending on the location of bpy-Ala, the tailor-made metalloenzymes exhibited electronically uncoupled or coupled dicopper sites. Consequently, they displayed various reactivities with dioxygen associated with multiple protons and electrons, illustrating a diverse chemical repertoire of artificial copper-dependent enzymes. | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Symmetry-Adapted Synthesis of Dicopper Oxidases with Divergent Dioxygen Reactivity | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acs.inorgchem.2c01898 | - |
dc.citation.journaltitle | Inorganic Chemistry | - |
dc.identifier.wosid | 000834100800001 | - |
dc.identifier.scopusid | 2-s2.0-85135599269 | - |
dc.citation.endpage | 12441 | - |
dc.citation.number | 31 | - |
dc.citation.startpage | 12433 | - |
dc.citation.volume | 61 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Song, Woon Ju | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ARTIFICIAL METALLOPROTEINS | - |
dc.subject.keywordPlus | 4-ELECTRON REDUCTION | - |
dc.subject.keywordPlus | MULTICOPPER OXIDASES | - |
dc.subject.keywordPlus | 2-ELECTRON REDUCTION | - |
dc.subject.keywordPlus | ELECTRONIC-STRUCTURE | - |
dc.subject.keywordPlus | MONONUCLEAR COPPER | - |
dc.subject.keywordPlus | HYDROGEN-PEROXIDE | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | ACTIVE-SITE | - |
dc.subject.keywordPlus | MECHANISM | - |
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