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High low-density lipoprotein cholesterol level is associated with an increased risk of incident early-onset vasomotor symptoms
DC Field | Value | Language |
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dc.contributor.author | Choi, Hye Rin | - |
dc.contributor.author | Chang, Yoosoo | - |
dc.contributor.author | Kim, Yejin | - |
dc.contributor.author | Kang, Jeonggyu | - |
dc.contributor.author | Kwon, Min-Jung | - |
dc.contributor.author | Kwon, Ria | - |
dc.contributor.author | Lim, Ga-Young | - |
dc.contributor.author | Kim, Kye-Hyun | - |
dc.contributor.author | Kim, Hoon | - |
dc.contributor.author | Hong, Yun Soo | - |
dc.contributor.author | Zhao, Di | - |
dc.contributor.author | Cho, Juhee | - |
dc.contributor.author | Guallar, Eliseo | - |
dc.contributor.author | Park, Hyun-Young | - |
dc.contributor.author | Ryu, Seungho | - |
dc.date.accessioned | 2022-10-11T01:16:02Z | - |
dc.date.available | 2022-10-11T01:16:02Z | - |
dc.date.created | 2022-09-08 | - |
dc.date.issued | 2022-08 | - |
dc.identifier.citation | Scientific Reports, Vol.12 No.1, p. 14652 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/10371/185720 | - |
dc.description.abstract | We investigated the associations between serum lipid profiles and risk of early-onset vasomotor symptoms (VMSs) in premenopausal women. This cohort study comprised 2,540 premenopausal women aged 42-52 years without VMSs at baseline (median follow-up: 4.4 years). VMSs, including hot flashes and night sweats, were assessed using the Menopause-Specific Quality of Life questionnaire (Korean version). Early-onset VMSs were defined as VMSs that occurred premenopause; moderate/severe VMSs were defined as a score of >= 3 points (range: 0 to 6, 6 being most bothersome). Cox proportional hazard regression models were used to estimate hazard ratios with 95% confidence intervals (CI) for the development of VMSs across the lipid levels. Higher low-density lipoprotein (LDL) cholesterol levels were positively associated with increased risk of early-onset VMSs. Compared to the < 100 mg/dL LDL group, the multivariable-adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) for incident VMSs were 1.19 (1.03-1.37) and 1.20 (1.03-1.40) in participants with LDL cholesterol levels of 100-129 mg/dL and >= 130 mg/dL, respectively (P for trend = 0.027). The multivariable-adjusted HR for incident moderate/severe VMSs was 1.37 (95% CI: 1.08-1.73) in participants with LDL >= 130 mg/dL, compared to those with LDL < 100 mg/dL. Meanwhile, triglycerides and total and high-density lipoprotein cholesterol levels were not significantly associated with early-onset VMSs risk in premenopausal women. Premenopausal women with high serum LDL cholesterol concentrations had a higher risk of incident early-onset VMSs. Further studies should confirm our findings and examine whether LDL-lowering interventions reduce the risk of early-onset VMSs among women during menopause transition. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | High low-density lipoprotein cholesterol level is associated with an increased risk of incident early-onset vasomotor symptoms | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-022-19028-4 | - |
dc.citation.journaltitle | Scientific Reports | - |
dc.identifier.wosid | 000846428600021 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 14652 | - |
dc.citation.volume | 12 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Hoon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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