Detailed Information

Correlation between Results of Semi-Quantitative and Quantitative Tests for Hepatitis B Virus Surface Antigen among Patients Achieving Viral Suppression with Antiviral Treatment

DC Field Value Language
dc.contributor.authorChung, Goh Eun-
dc.contributor.authorKim, Ju Yeon-
dc.contributor.authorShin, Hyunjae-
dc.contributor.authorHong, Ji Hoon-
dc.contributor.authorHur, Moon Haeng-
dc.contributor.authorCho, Heejin-
dc.contributor.authorPark, Min Kyung-
dc.contributor.authorChoi, Na Ryung-
dc.contributor.authorKim, Jihye-
dc.contributor.authorLee, Yun Bin-
dc.contributor.authorCho, Eun Ju-
dc.contributor.authorYu, Su Jong-
dc.contributor.authorKim, Yoon Jun-
dc.contributor.authorYoon, Jung-Hwan-
dc.contributor.authorLee, Jeong-Hoon-
dc.identifier.citationDiagnostics, Vol.12 No.7, p. 1757-
dc.description.abstractBackground: Hepatitis B virus (HBV) infection remains a threat to global public health. Serum hepatitis B surface antigen (HBsAg) has been used in screening for HBV infection. Quantitative HBsAg assays are useful for monitoring the natural history of HBV infection and its response to therapy. The aim of this study was to determine the relationship between quantitative (qHBsAg; IU/mL) and semi-quantitative (sqHBsAg; signal-to-cutoff ratio [S/Co]) HBsAg titers in patients with chronic hepatitis B (CHB). Methods: We retrospectively included 284 samples with HBV DNA < 20 IU/mL from patients who had simultaneous qHBsAg (using electrochemiluminescence assay) and sqHBsAg tests. Patients were grouped according to their serum HBV-envelope antigen (HBeAg) status (HBeAg-negative, n = 239 and HBeAg-positive, n = 45). The Spearman test was used to analyze the correlation between the quantitative and semi-quantitative assays. Results: There was a significant linear correlation between sqHBsAg and qHBsAg in the HBeAg-negative patients (qHBsAg [IU/mL] = 0.0094 x sqHBsAg [S/Co](1.323); adjusted R-2 = 0.8445; p < 0.001). There was a substantial hook effect in the assays from the HBeAg-positive patients, so we performed a stratified analysis according to qHBsAg <1000 IU/mL or >= 1000 IU/mL and found a significant positive linear correlation between sqHBsAg S/Co and qHBsAg (qHBsAg [IU/mL] = 0.072 x sqHBsAg [S/Co](1.331); adjusted R-2 = 0.7878; p < 0.001) in HBeAg-positive patients with qHBsAg titers of <1000 IU/mL and a significant negative correlation in HBeAg-positive patients with qHBsAg titers of >= 1000 IU/mL (qHBsAg [IU/mL] = 8.987 x 10(14) x sqHBsAg [S/Co](-3.175); adjusted R-2 = 0.6350; p < 0.001). Conclusions: There was a highly linear, positive correlation between qHBsAg and sqHBsAg in HBeAg-negative CHB patients. The hook effect led to a negative correlation in HBeAg-positive CHB patients with qHBsAg titers >= 1000 IU/mL.-
dc.publisherMDPI AG-
dc.titleCorrelation between Results of Semi-Quantitative and Quantitative Tests for Hepatitis B Virus Surface Antigen among Patients Achieving Viral Suppression with Antiviral Treatment-
dc.contributor.affiliatedAuthorKim, Yoon Jun-
dc.contributor.affiliatedAuthorYoon, Jung-Hwan-
Appears in Collections:
Files in This Item:
There are no files associated with this item.


Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.