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Efficacy and safety of larotrectinib in patients with TRK fusion-positive thyroid carcinoma

Cited 47 time in Web of Science Cited 52 time in Scopus

Waguespack, Steven G.; Drilon, Alexander; Lin, Jessica J.; Brose, Marcia S.; McDermott, Ray; Almubarak, Mohammed; Bauman, Jessica; Casanova, Michela; Krishnamurthy, Anuradha; Kummar, Shivaani; Leyvraz, Serge; Oh, Do-Youn; Park, Keunchil; Sohal, Davendra; Sherman, Eric; Norenberg, Ricarda; Silvertown, Josh D.; Brega, Nicoletta; Hong, David S.; Cabanillas, Maria E.

Issue Date
BioScientifica Ltd.
European Journal of Endocrinology, Vol.187 No.1, pp.631-643
© 2022 The authors.Objective: Larotrectinib is a highly selective tropomyosin receptor kinas e (TRK) inhibitor with demonstrated efficacy across various TRK fusion-positive solid tumours. We assessed t he efficacy and safety of larotrectinib in patients with TRK fusion-positive thyroid carcinoma (TC). Methods: We pooled data from three phase I/II larotrectinib clinical trials (NCT02576431, NCT02122913, and NCT02637687). The primary endpoint was the investigator-assessed objective response rate (ORR) per Response Evaluation Criteria in Solid Tumors v1.1. Secondary endpoints i ncluded duration of response (DoR), progression-free survival (PFS), overall survival (OS), and safety. Data cut-off: July 2020. Results: Twenty-nine patients (median age: 60; range: 6-80) with TRK fu sion-positive TC were treated. Tumour histology was papillary (PTC) in 20 (69%) patients, follicular (FTC) in 2 (7%), and anaplastic (ATC) in 7 (24%) patients. Among 28 evaluable patients, ORR was 71% (95% CI: 51-87); best responses were complete response in 2 (7%) patients, partial response in 18 (64%), stable disease in 4 (14%), progressive di sease in 3 (11%), and undetermined in 1 (4%) due to clinical progression prior to the first post-baseline assessment . ORR was 86% (95% CI: 64-97) for PTC/FTC and 29% (95% CI 4-71) for ATC. Median time to response was 1.87 months (range 1.64-3.68). The 24-month DoR, PFS, and OS rates were 81, 69, and 76%, respectively. Treatment-related adv erse events were mainly grades 1-2. Conclusion: In TRK fusion-positive TC, larotrectinib demonstrates rapid an d durable disease control and a favourable safety profile in patients with advanced disease requiring syste mic therapy.
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