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The role of the serum 25-OH vitamin D level on detecting prostate cancer in men with elevated prostate-specific antigen levels
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Min Hyuk | - |
dc.contributor.author | Yoo, Sangjun | - |
dc.contributor.author | Choo, Min Soo | - |
dc.contributor.author | Cho, Min Chul | - |
dc.contributor.author | Son, Hwancheol | - |
dc.contributor.author | Jeong, Hyeon | - |
dc.date.accessioned | 2022-10-12T00:54:19Z | - |
dc.date.available | 2022-10-12T00:54:19Z | - |
dc.date.created | 2022-09-02 | - |
dc.date.issued | 2022-08 | - |
dc.identifier.citation | Scientific Reports, Vol.12 No.1, p. 14089 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/10371/185894 | - |
dc.description.abstract | We aimed to determine whether vitamin D levels before prostate biopsy have diagnostic value for clinically significant prostate cancer. The study cohort included patients who underwent prostate biopsy. A total of 224 patients were enrolled in our study and serum vitamin D levels were measured from February 2016 to December 2019 in routine laboratory tests. To determine the relationship between vitamin D levels and aggressiveness of prostate cancer, we used logistic multivariate analysis. Based on the histopathological results of patients who underwent radical prostatectomy, the serum vitamin D level was significantly lower with the large tumor volume group. In the univariate analysis, the prostate cancer diagnosis rate was associated with low vitamin D levels. Low vitamin D level is negatively correlated with clinically significant prostate cancer (biopsy Gleason score of 7 or higher) in the univariate (Odds ratio [OR], 0.955; P < 0.001) and multivariate (OR, 0.944; P = 0.027) analyses. In conclusion, we found that the incidence of clinically significant prostate cancer might related to low vitamin D level in the Asian population. In the future, a larger population and prospective study are needed. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | The role of the serum 25-OH vitamin D level on detecting prostate cancer in men with elevated prostate-specific antigen levels | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-022-17563-8 | - |
dc.citation.journaltitle | Scientific Reports | - |
dc.identifier.wosid | 000841942700049 | - |
dc.identifier.scopusid | 2-s2.0-85136128457 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 14089 | - |
dc.citation.volume | 12 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Son, Hwancheol | - |
dc.contributor.affiliatedAuthor | Jeong, Hyeon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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