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Long-term use of renin-angiotensin-system inhibitors after acute myocardial infarction is not associated with survival benefits: Analysis of data from the Korean acute myocardial infarction registry-national institutes of health registry
DC Field | Value | Language |
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dc.contributor.author | Park, Chan Soon | - |
dc.contributor.author | Yang, Han-Mo | - |
dc.contributor.author | Kang, Jeehoon | - |
dc.contributor.author | Han, Jung-Kyu | - |
dc.contributor.author | Park, Kyung Woo | - |
dc.contributor.author | Kang, Hyun-Jae | - |
dc.contributor.author | Koo, Bon-Kwon | - |
dc.contributor.author | Seung, Ki-Bae | - |
dc.contributor.author | Cha, Kwang Soo | - |
dc.contributor.author | Seong, In-Whan | - |
dc.contributor.author | Rha, Seung-Woon | - |
dc.contributor.author | Jeong, Myung Ho | - |
dc.contributor.author | Kim, Hyo-Soo | - |
dc.contributor.author | KAMIR-NIH Registry | - |
dc.date.accessioned | 2022-10-17T04:17:19Z | - |
dc.date.available | 2022-10-17T04:17:19Z | - |
dc.date.created | 2022-10-13 | - |
dc.date.issued | 2022-08 | - |
dc.identifier.citation | Frontiers in Cardiovascular Medicine, Vol.9, p. 994419 | - |
dc.identifier.issn | 2297-055X | - |
dc.identifier.uri | https://hdl.handle.net/10371/186188 | - |
dc.description.abstract | Introduction: Renin-angiotensin-system inhibitors (RASi) have shown survival benefits after acute myocardial infarction (MI), but the role of routine long-term use of RASi remains unclear. Thereby, we explored the therapeutic effects of RASi medication at 1-year follow-up from acute MI. Methods: Using the nationwide Korea Acute Myocardial Infarction Registry-National Institutes of Health (KAMIR-NIH) registry, we included and analyzed 10,822 subjects. Patients were stratified into those taking RASi at 1-year follow-up (n = 7,696) and those not taking RASi at 1-year follow-up (n = 3,126). Patients were followed up for 2-years from the 1-year follow-up; 2-year all-cause mortality and cardiac mortality were analyzed as primary and secondary outcomes, respectively. Results: The use of RASi at 1-year follow-up was not associated with decreased all-cause mortality (log-rank P = 0.195) or cardiac mortality (log-rank P = 0.337). In multivariate analyses, RASi medication at 1-year follow-up did not reduce all-cause mortality (P = 0.758) or cardiac mortality (P = 0.923), while RASi medication at discharge substantially reduced 1-year all-cause and cardiac mortality. Treatment with either an angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker at 1-year follow-up did not show survival benefits from 1-year follow-up, respectively. The use of RASi at 1-year follow-up did not show a prognostic interaction between previous history of chronic kidney disease, post-MI acute heart failure, concomitant use of beta-blockers at 1-year follow-up, or 1-year LVEF. Conclusion: Acute MI patients taking RASi at 1-year follow-up were not associated with improved 2-year all-cause mortality or cardiac mortality from the 1-year follow-up. This study provides valuable information regarding tailored medication strategy after acute MI. | - |
dc.language | 영어 | - |
dc.publisher | Frontiers Media S.A. | - |
dc.title | Long-term use of renin-angiotensin-system inhibitors after acute myocardial infarction is not associated with survival benefits: Analysis of data from the Korean acute myocardial infarction registry-national institutes of health registry | - |
dc.type | Article | - |
dc.identifier.doi | 10.3389/fcvm.2022.994419 | - |
dc.citation.journaltitle | Frontiers in Cardiovascular Medicine | - |
dc.identifier.wosid | 000859512600001 | - |
dc.identifier.scopusid | 2-s2.0-85138379312 | - |
dc.citation.startpage | 994419 | - |
dc.citation.volume | 9 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kang, Hyun-Jae | - |
dc.contributor.affiliatedAuthor | Koo, Bon-Kwon | - |
dc.contributor.affiliatedAuthor | Kim, Hyo-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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