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Effect of selenium-free parenteral nutrition on serum selenium of neonates and infants maintained on long-term parenteral nutrition
DC Field | Value | Language |
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dc.contributor.author | Lee, Ji Young | - |
dc.contributor.author | Shin, Hyun Jung | - |
dc.contributor.author | Bae, Hye Jung | - |
dc.contributor.author | Jo, Yun Hee | - |
dc.contributor.author | Cho, Yoon Sook | - |
dc.contributor.author | Shin, Seung Han | - |
dc.contributor.author | Kim, Ee-Kyung | - |
dc.contributor.author | Kim, Han-Suk | - |
dc.date.accessioned | 2022-10-17T04:17:34Z | - |
dc.date.available | 2022-10-17T04:17:34Z | - |
dc.date.created | 2022-07-27 | - |
dc.date.issued | 2022-07 | - |
dc.identifier.citation | Journal of Parenteral and Enteral Nutrition, Vol.46 No.5, pp.1045-1053 | - |
dc.identifier.issn | 0148-6071 | - |
dc.identifier.uri | https://hdl.handle.net/10371/186205 | - |
dc.description.abstract | © 2021 American Society for Parenteral and Enteral Nutrition.Background: The risk of selenium deficiency increases for infants receiving long-term parenteral nutrition (PN). This study analyzed selenium deficiency in neonates and infants requiring long-term PN and evaluated the effect of intravenous (IV) selenium provision. Methods: This study was a retrospective study of neonates and infants who were admitted to a neonatal intensive care unit from January 2010 to December 2019, received PN for ≥2 weeks, and had their serum selenium concentration measured. Patients were divided into two groups, depending on their serum selenium concentration, a deficient group (n = 55) and a nondeficient group (n = 47). Results: Of the study participants, 53.9% (55 of 102) were deficient in selenium. No difference in demographic and clinical characteristics existed except bronchopulmonary dysplasia. A subgroup analysis was performed for patients (n = 29). The average dose of IV selenium administered to patients was 2.7 ± 1.0 mcg/kg/day. The average initial serum selenium concentration was 36.5 ± 18.0 mcg/L, and the serum concentration significantly increased to 52.5 ± 19.1 mcg/L after IV selenium administration (P <.001). The correlation between the average IV selenium dose and the change in serum selenium concentrations was statistically significant (r =.423; P =.022). Conclusion: Selenium deficiency is common in neonates and infants receiving long-term PN. Serum selenium concentration increased proportionally as the IV selenium dose increased. Therefore, it is recommended to supply a proper dose of IV selenium depending on the degree of selenium deficiency. | - |
dc.language | 영어 | - |
dc.publisher | SAGE Publications | - |
dc.title | Effect of selenium-free parenteral nutrition on serum selenium of neonates and infants maintained on long-term parenteral nutrition | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/jpen.2281 | - |
dc.citation.journaltitle | Journal of Parenteral and Enteral Nutrition | - |
dc.identifier.wosid | 000715945600001 | - |
dc.identifier.scopusid | 2-s2.0-85118635253 | - |
dc.citation.endpage | 1053 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 1045 | - |
dc.citation.volume | 46 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Ee-Kyung | - |
dc.contributor.affiliatedAuthor | Kim, Han-Suk | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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