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NRF2 activation by 2-methoxycinnamaldehyde attenuates inflammatory responses in macrophages via enhancing autophagy flux
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Bo-Sung | - |
dc.contributor.author | Shin, Minwook | - |
dc.contributor.author | Kim, Kyu-Won | - |
dc.contributor.author | Ha, Ki-Tae | - |
dc.contributor.author | Bae, Sung-Jin | - |
dc.date.accessioned | 2022-10-17T04:47:16Z | - |
dc.date.available | 2022-10-17T04:47:16Z | - |
dc.date.created | 2022-10-13 | - |
dc.date.issued | 2022-08 | - |
dc.identifier.citation | BMB Reports, Vol.55 No.8, pp.407-412 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://hdl.handle.net/10371/186381 | - |
dc.description.abstract | A well-controlled inflammatory response is crucial for the recovery from injury and maintenance of tissue homeostasis. The anti-inflammatory response of 2-methoxycinnamaldehyde (2-MCA), a natural compound derived from cinnamon, has been studied; however, the underlying mechanism on macrophage has not been fully elucidated. In this study, LPS-stimulated production of TNF-alpha and NO was reduced by 2-MCA in macrophages. 2-MCA significantly activated the NRF2 pathway, and expression levels of autophagy-associated proteins in macrophages, including LC3 and P62, were enhanced via NRF2 activation regard-less of LPS treatment, suggesting the occurrence of 2-MCA -mediated autophagy. Moreover, evaluation of autophagy flux using luciferase-conjugated LC3 revealed that incremental LC3 and P62 levels are coupled to enhanced autophagy flux. Finally, reduced expression levels of TNF-alpha and NOS2 by 2-MCA were reversed by autophagy inhibitors, such as bafilomycin A1 and NH4Cl, in LPS-stimulated macrophages. In conclusion, 2-MCA enhances autophagy flux in macrophages via NRF2 activation and consequently reduces LPS-induced inflammation. | - |
dc.language | 영어 | - |
dc.publisher | 생화학분자생물학회 | - |
dc.title | NRF2 activation by 2-methoxycinnamaldehyde attenuates inflammatory responses in macrophages via enhancing autophagy flux | - |
dc.type | Article | - |
dc.identifier.doi | 10.5483/BMBRep.2022.55.8.065 | - |
dc.citation.journaltitle | BMB Reports | - |
dc.identifier.wosid | 000861372500007 | - |
dc.identifier.scopusid | 2-s2.0-85137134997 | - |
dc.citation.endpage | 412 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | 407 | - |
dc.citation.volume | 55 | - |
dc.identifier.kciid | ART002870437 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Kyu-Won | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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