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The Haemophilus influenzae HipBA toxin-antitoxin system adopts an unusual three-component regulatory mechanism
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Koo, Ji Sung | - |
dc.contributor.author | Kang, Sung-Min | - |
dc.contributor.author | Jung, Won-Min | - |
dc.contributor.author | Kim, Do-Hee | - |
dc.contributor.author | Lee, Bong-Jin | - |
dc.date.accessioned | 2022-10-18T00:32:57Z | - |
dc.date.available | 2022-10-18T00:32:57Z | - |
dc.date.created | 2022-10-13 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.citation | IUCrJ, Vol.9, pp.625-631 | - |
dc.identifier.issn | 2052-2525 | - |
dc.identifier.uri | https://hdl.handle.net/10371/186396 | - |
dc.description.abstract | Type II toxin-antitoxin (TA) systems encode two proteins: a toxin that inhibits cell growth and an antitoxin that neutralizes the toxin by direct intermolecular protein-protein interactions. The bacterial HipBA TA system is implicated in persister formation. The Haemophilus influenzae HipBATA system consists of a HipB antitoxin and a HipA toxin, the latter of which is split into two fragments, and here we investigate this novel three-component regulatory HipBA system. Structural and functional analysis revealed that HipA(N) corresponds to the N-terminal part of HipA from other bacteria and toxic HipA(C) is inactivated by HipA(N), not HipB. This study will be helpful in understanding the detailed regulatory mechanism of the HipBA(N+C) system, as well as why it is constructed as a three-component system. | - |
dc.language | 영어 | - |
dc.publisher | International Union of Crystallography | - |
dc.title | The Haemophilus influenzae HipBA toxin-antitoxin system adopts an unusual three-component regulatory mechanism | - |
dc.type | Article | - |
dc.identifier.doi | 10.1107/S205225252200687X | - |
dc.citation.journaltitle | IUCrJ | - |
dc.identifier.wosid | 000852551800012 | - |
dc.citation.endpage | 631 | - |
dc.citation.startpage | 625 | - |
dc.citation.volume | 9 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Bong-Jin | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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