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Obesity and effects of dapagliflozin on cardiovascular and renal outcomes in patients with type 2 diabetes mellitus in the DECLARE-TIMI 58 trial
DC Field | Value | Language |
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dc.contributor.author | Oyama, Kazuma | - |
dc.contributor.author | Raz, Itamar | - |
dc.contributor.author | Cahn, Avivit | - |
dc.contributor.author | Kuder, Julia | - |
dc.contributor.author | Murphy, Sabina A. | - |
dc.contributor.author | Bhatt, Deepak L. | - |
dc.contributor.author | Leiter, Lawrence A. | - |
dc.contributor.author | McGuire, Darren K. | - |
dc.contributor.author | Wilding, John P H | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.contributor.author | Goudev, Assen | - |
dc.contributor.author | Diaz, Rafael | - |
dc.contributor.author | Špinar, Jindřich | - |
dc.contributor.author | Gause-Nilsson, Ingrid A M | - |
dc.contributor.author | Mosenzon, Ofri | - |
dc.contributor.author | Sabatine, Marc S. | - |
dc.contributor.author | Wiviott, Stephen D. | - |
dc.date.accessioned | 2022-10-19T05:25:47Z | - |
dc.date.available | 2022-10-19T05:25:47Z | - |
dc.date.created | 2022-10-11 | - |
dc.date.issued | 2022-08 | - |
dc.identifier.citation | European Heart Journal, Vol.43 No.31, pp.2958-2967 | - |
dc.identifier.issn | 0195-668X | - |
dc.identifier.uri | https://hdl.handle.net/10371/186499 | - |
dc.description.abstract | Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.AIMS : We investigated the associations between obesity, cardiorenal events, and benefits of dapagliflozin in patients with type 2 diabetes mellitus (T2DM). METHODS AND RESULTS : DECLARE-TIMI 58 randomized patients with T2DM and either atherosclerotic cardiovascular (CV) disease or multiple risk factors to dapagliflozin vs. placebo. Patients were stratified by body mass index (BMI, kg/m2): normal (18.5 to <25), overweight (25 to <30), moderately obese (30 to <35), severely obese (35 to <40), and very-severely obese (≥40). Outcomes analysed were CV death, hospitalization for heart failure (HHF), renal-specific composite outcome, and atrial fibrillation or flutter (AF/AFL). Of 17 134 patients, 9.0% had a normal BMI, 31.5% were overweight, 32.4% were moderately, 17.2% severely, and 9.8% were very-severely obese. Higher BMI was associated with a higher adjusted risk of HHF and AF/AFL (hazard ratio 1.30 and 1.28, respectively, per 5 kg/m2; P < 0.001 for all). Dapagliflozin reduced body weight by similar relative amounts consistently across BMI categories (percent difference: -1.9 to -2.4%). Although relative risk reductions in CV and renal-specific composite outcomes with dapagliflozin did not significantly differ across the range of BMI (P for interaction ≥0.20 for all outcomes), obese patients (BMI ≥ 30 kg/m2) tended to derive greater absolute risk reduction in HHF and AF/AFL (P for interaction 0.02 and 0.09, respectively) than non-obese patients. CONCLUSIONS : In DECLARE-TIMI 58, patients with T2DM and higher BMI were more likely to have HHF and AF/AFL. Whereas relative risk reductions in CV and renal outcomes with dapagliflozin were generally consistent across the range of BMI, absolute risk reduction in obesity-related outcomes including HHF and AF/AFL tended to be larger in obese patients with T2DM. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifiers: NCT01730534. | - |
dc.language | 영어 | - |
dc.publisher | Oxford University Press | - |
dc.title | Obesity and effects of dapagliflozin on cardiovascular and renal outcomes in patients with type 2 diabetes mellitus in the DECLARE-TIMI 58 trial | - |
dc.type | Article | - |
dc.identifier.doi | 10.1093/eurheartj/ehab530 | - |
dc.citation.journaltitle | European Heart Journal | - |
dc.identifier.wosid | 000756673900001 | - |
dc.identifier.scopusid | 2-s2.0-85124708242 | - |
dc.citation.endpage | 2967 | - |
dc.citation.number | 31 | - |
dc.citation.startpage | 2958 | - |
dc.citation.volume | 43 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Park, Kyong Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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