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Association between Vitamin C Deficiency and Mortality in Patients with Septic Shock
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Jong Eun | - |
dc.contributor.author | Shin, Tae Gun | - |
dc.contributor.author | Jeong, Daun | - |
dc.contributor.author | Lee, Gun Tak | - |
dc.contributor.author | Ryoo, Seung Mok | - |
dc.contributor.author | Kim, Won Young | - |
dc.contributor.author | Jo, You Hwan | - |
dc.contributor.author | Suh, Gil Joon | - |
dc.contributor.author | Hwang, Sung Yeon | - |
dc.date.accessioned | 2022-10-20T02:26:25Z | - |
dc.date.available | 2022-10-20T02:26:25Z | - |
dc.date.created | 2022-10-07 | - |
dc.date.created | 2022-10-07 | - |
dc.date.created | 2022-10-07 | - |
dc.date.created | 2022-10-07 | - |
dc.date.created | 2022-10-07 | - |
dc.date.created | 2022-10-07 | - |
dc.date.created | 2022-10-07 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.citation | Biomedicines, Vol.10 No.9, p. 2090 | - |
dc.identifier.issn | 2227-9059 | - |
dc.identifier.uri | https://hdl.handle.net/10371/186565 | - |
dc.description.abstract | The prognostic value of low vitamin C levels has not been well investigated in patients with septic shock. We aimed to evaluate the association of vitamin C deficiency with mortality in patients with septic shock. We conducted a retrospective analysis of 165 patients with septic shock from a prospective multicenter trial and institutional sepsis registry between April 2018 and January 2020. The primary outcome was 28-day mortality. The patients were categorized into vitamin C deficiency and normal groups based on a vitamin C cutoff level of 11.4 mmol/L. Multivariable Cox regression analysis was performed to examine the association between vitamin C levels and 28-day mortality. A total of 165 patients was included for analysis and 77 (46.7%) had vitamin C deficiency. There was no significant difference in the 28-day mortality rate between the vitamin C deficiency group and the normal group (23.4% (n = 18/77) vs. 13.6% (n = 12/88), p = 0.083). Multivariable Cox proportional hazard analysis showed vitamin C deficiency to be associated with increased risk of 28-day mortality (adjusted hazard ratio, 2.65, 95% confidence interval (CI), 1.08-6.45; p = 0.032). Initial vitamin C deficiency was associated with a higher risk of 28-day mortality in patients with septic shock after adjusting for intravenous administration of vitamin C and thiamine, baseline characteristics, laboratory findings, and severity of illness. | - |
dc.language | 영어 | - |
dc.publisher | MDPI AG | - |
dc.title | Association between Vitamin C Deficiency and Mortality in Patients with Septic Shock | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/biomedicines10092090 | - |
dc.citation.journaltitle | Biomedicines | - |
dc.identifier.wosid | 000858489100001 | - |
dc.identifier.scopusid | 2-s2.0-85138633360 | - |
dc.citation.number | 9 | - |
dc.citation.startpage | 2090 | - |
dc.citation.volume | 10 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Jo, You Hwan | - |
dc.contributor.affiliatedAuthor | Suh, Gil Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ASCORBIC-ACID | - |
dc.subject.keywordPlus | ORGAN FAILURE | - |
dc.subject.keywordPlus | SEPSIS | - |
dc.subject.keywordPlus | ALBUMIN | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | ILL | - |
dc.subject.keywordAuthor | sepsis | - |
dc.subject.keywordAuthor | septic shock | - |
dc.subject.keywordAuthor | ascorbic acid | - |
dc.subject.keywordAuthor | mortality | - |
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