Publications
Detailed Information
Correlations between clinical parameters of dry eye disease and serologic profiles in Sjogren's syndrome
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yunjin | - |
dc.contributor.author | Jeon, Hyun Sun | - |
dc.contributor.author | Hyon, Joon Young | - |
dc.date.accessioned | 2022-10-20T02:26:34Z | - |
dc.date.available | 2022-10-20T02:26:34Z | - |
dc.date.created | 2022-09-16 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.citation | Graefe's Archive for Clinical and Experimental Ophthalmology, Vol.260 No.9, pp.2925-2932 | - |
dc.identifier.issn | 0721-832X | - |
dc.identifier.uri | https://hdl.handle.net/10371/186578 | - |
dc.description.abstract | © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.Purpose: To investigate the difference in clinical parameters of dry eye disease (DED) according to the presence of serum anti-La antibodies and evaluate the correlations of autoantibody titers with DED parameters in patients with primary Sjögrens syndrome (pSS). Methods: Sixty-two patients diagnosed with pSS according to the 2016 ACR-EULAR classification criteria were classified into two groups depending on the presence of anti-La antibodies: group 1 (anti-Ro positive alone, n = 31) and group 2 (both anti-Ro and anti-La positive, n = 31). DED parameters (conjunctival and corneal ocular staining score (OSS), tear film break-up time (TBUT), Schirmer I test, lipid layer thickness (LLT), meiboscore, and ocular surface disease index), serum autoantibodies (anti-Ro, anti-La, rheumatoid factor (RF), and antinuclear antibody) and focus score were assessed. Results: The DED parameters were not significantly different between the two groups (P > 0.05). The anti-Ro titers, RF-positive rate, and the focus score were significantly higher in group 2 than in group 1 (P = 0.001, P = 0.049, P = 0.001, respectively). The anti-Ro titers had a significant positive correlation with conjunctival OSS (r = 0.273, P = 0.033) and the focus score had a positive correlation with LLT and meiboscore (r = − 0.358, P = 0.072; r = 0.379, P = 0.056). Conclusion: In this study, anti-Ro titers significantly correlated with conjunctival staining score, whereas anti-La did not statistically correlated with clinical DED parameters in SS. Meanwhile, anti-Ro titers and focus score were significantly higher in patients positive for both anti-Ro and anti-La, which suggests that examining anti-La with anti-Ro would be helpful in predicting clinical severities of SS patients. | - |
dc.language | 영어 | - |
dc.publisher | Springer Verlag | - |
dc.title | Correlations between clinical parameters of dry eye disease and serologic profiles in Sjogren's syndrome | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s00417-022-05671-0 | - |
dc.citation.journaltitle | Graefe's Archive for Clinical and Experimental Ophthalmology | - |
dc.identifier.wosid | 000785940200001 | - |
dc.identifier.scopusid | 2-s2.0-85128732257 | - |
dc.citation.endpage | 2932 | - |
dc.citation.number | 9 | - |
dc.citation.startpage | 2925 | - |
dc.citation.volume | 260 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Jeon, Hyun Sun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.