Detailed Information

Association of Left Ventricular Diastolic Dysfunction With Cardiovascular Outcomes in Patients With Pre-dialysis Chronic Kidney Disease: Findings From KNOW-CKD Study

Cited 9 time in Web of Science Cited 9 time in Scopus

Suh, Sang Heon; Oh, Tae Ryom; Choi, Hong Sang; Kim, Chang Seong; Bae, Eun Hui; Oh, Kook-Hwan; Choi, Kyu Hun; Oh, Yun Kyu; Ma, Seong Kwon; Kim, Soo Wan

Issue Date
Frontiers Media S.A.
Frontiers in Cardiovascular Medicine, Vol.9, p. 844312
BackgroundThe impact of left ventricular diastolic dysfunction (LVDD) on cardiovascular (CV) outcomes in patients with pre-dialysis chronic kidney disease (CKD) has been rarely unveiled. We here investigated the association of LVDD with CV outcomes and all-cause mortality in patients with pre-dialysis CKD. MethodsA total of 2,135 patients with pre-dialysis CKD from the Korean Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) cohort were dichotomized by the absence or presence of LVDD, which was defined as the ratio of the early transmitral blood flow velocity to early diastolic velocity of the mitral annulus (E/e ') > 14. ResultsCox regression analysis revealed that LVDD was significantly associated with increased risk of composite CV events [adjusted hazard ratio (HR) 2.194, 95% confidence interval (CI) 1.486-3.240] and all-cause mortality (adjusted HR 1.830, 95% CI 1.168-2.869). Restricted cubic splines visualized stringent linear correlations of E/e ' with both composite CV events and all-cause mortality. In the sensitivity analysis only including the subjects with left ventricular ejection fraction >= 50%, LVDD was still significantly associated with adverse CV outcomes (adjusted HR 1.984, 95% CI 1.325-3.000) and all-cause mortality (adjusted HR 1.727, 95% CI 1.083-2.754), suggesting that the impact of LVDD on the outcomes in patients with CKD is independent of LV systolic function. Subgroup analyses revealed that the associations were not modified by various clinical contexts, such as age, sex, burden of comorbid conditions, body mass index, estimated glomerular filtration rate, and albuminuria. ConclusionLVDD is independently associated with adverse CV outcomes and all-cause mortality in patients with pre-dialysis CKD.
Files in This Item:
There are no files associated with this item.
Appears in Collections:


Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.