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Prediction of malignancy in main duct or mixed-type intraductal papillary mucinous neoplasms of the pancreas
DC Field | Value | Language |
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dc.contributor.author | Jung, Hye-Sol | - |
dc.contributor.author | Han, Youngmin | - |
dc.contributor.author | Kang, Jae Seung | - |
dc.contributor.author | Sohn, Heeju | - |
dc.contributor.author | Lee, Mirang | - |
dc.contributor.author | Lee, Kyung-Bun | - |
dc.contributor.author | Kim, Hongbeom | - |
dc.contributor.author | Kwon, Wooil | - |
dc.contributor.author | Jang, Jin-Young | - |
dc.date.accessioned | 2022-11-11T08:15:23Z | - |
dc.date.available | 2022-11-11T08:15:23Z | - |
dc.date.created | 2022-10-19 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.citation | Journal of Hepato-Biliary-Pancreatic Sciences, Vol.29 No.9, pp.1014-1024 | - |
dc.identifier.issn | 1868-6974 | - |
dc.identifier.uri | https://hdl.handle.net/10371/187099 | - |
dc.description.abstract | © 2022 Japanese Society of Hepato-Biliary-Pancreatic Surgery.Background/Purpose: Surgical indications of main duct-involved intraductal papillary mucinous neoplasm (IPMN), especially for main pancreatic duct (MPD) of 5-9 mm, remain controversial. We aimed to predict malignancy risk of main duct-involved IPMN. Methods: Total 258 patients with main duct-involved IPMN between 2000 and 2017 in our institute were retrospectively analyzed. Main duct IPMN was classified into segmental and diffuse-type by dilated MPD pattern. Clinicopathologic features and predictive factors for malignancy were analyzed. Results: Among 258 patients, 47 and 211 had pure main duct (segmental: 27, diffuse type: 20) and mixed type, respectively. Malignant IPMN presented higher in main duct type (66.0%) compared to mixed type (46.9%). The diffuse type (72.2%) had more invasive carcinoma than the segmental type (40.7%). Invasive IPMN risk increased proportionally to the MPD diameter (5 ≤ MPD <10 mm vs 10 ≤ MPD < 15 mm vs MPD ≥ 15 mm; 23.4% vs 40.0% vs 48.6%). Symptoms, elevated serum carbohydrate antigen, MPD ≥10 mm, mural nodule, thickened wall, and distal atrophy were independent predictive factors for malignancy. Patients with MPD of 5-9 mm with at least one predictive factor had 35.0% of malignancy risk. Conclusions: The invasive IPMN risk was different according to the dilated main duct pattern. Patients with main duct type, diffuse type, MPD ≥10 mm, and MPD 5-9 mm with at least one predictive factor should be candidates for immediate surgery. | - |
dc.language | 영어 | - |
dc.publisher | Springer Verlag | - |
dc.title | Prediction of malignancy in main duct or mixed-type intraductal papillary mucinous neoplasms of the pancreas | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/jhbp.1161 | - |
dc.citation.journaltitle | Journal of Hepato-Biliary-Pancreatic Sciences | - |
dc.identifier.wosid | 000792510400001 | - |
dc.identifier.scopusid | 2-s2.0-85129671328 | - |
dc.citation.endpage | 1024 | - |
dc.citation.number | 9 | - |
dc.citation.startpage | 1014 | - |
dc.citation.volume | 29 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Jang, Jin-Young | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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