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Effects of Reproductive Factors on Lauren Intestinal-Type Gastric Cancers in Females: A Multicenter Retrospective Study in South Korea
DC Field | Value | Language |
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dc.contributor.author | Jung, Yoon Ju | - |
dc.contributor.author | Kim, Hee Jin | - |
dc.contributor.author | Park, Cho Hyun | - |
dc.contributor.author | Park, Seun Ja | - |
dc.contributor.author | Kim, Nayoung | - |
dc.date.accessioned | 2022-11-23T00:44:45Z | - |
dc.date.available | 2022-11-23T00:44:45Z | - |
dc.date.created | 2022-10-14 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.citation | Gut and Liver, Vol.16 No.5, pp.706-715 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.uri | https://hdl.handle.net/10371/187224 | - |
dc.description.abstract | Copyright © Gut and Liver.Background/Aims: Gastric cancers (GCs), particularly the Lauren intestinal type, show a male predominance. The aim of this study was to investigate the effects of reproductive factors on GCs in females, according to Lauren classification. Methods: Medical records of 1,849 males and 424 females who underwent radical gastrectomy or endoscopic resection for GCs between 2010 and 2018 were reviewed. The incidences of intestinal-type GCs were compared between males and groups of females stratified according to postmenopausal period. Associations between reproductive factors in females and intestinal-type GCs were analyzed using multivariate models. Results: The proportions of intestinal-type GCs were significantly lower in premenopausal (19%), less than 10 years postmenopausal (30.4%), and 10 to 19 years postmenopausal females (44.1%) than in males (61.0%) (p<0.05 for all). Females ≥20 years postmenopause had a proportion of intestinal-type GCs similar to that in males (60.6% vs 61.0%; p=0.948). Multivariate analysis revealed that age (odds ratio [OR], 1.075; 95% confidence interval [CI], 1.039 to 1.113; p<0.001) and parity ≥3 (OR, 1.775; 95% CI, 1.012 to 3.114; p=0.045) were positively associated with an increased risk of intestinal-type GCs in postmenopausal females, while long fertility duration (OR, 1.147; 95% CI, 1.043 to 1.261; p=0.005) was positively associated with an increased risk of intestinal-type GCs in premenopausal females. Conclusions: There were no significant differences in the proportions of intestinal-type GCs between males and females ≥20 years postmenopause, suggesting that female reproductive factors play a role in the prevention of intestinal-type GC. | - |
dc.language | 영어 | - |
dc.publisher | 거트앤리버 발행위원회 | - |
dc.title | Effects of Reproductive Factors on Lauren Intestinal-Type Gastric Cancers in Females: A Multicenter Retrospective Study in South Korea | - |
dc.type | Article | - |
dc.identifier.doi | 10.5009/gnl210293 | - |
dc.citation.journaltitle | Gut and Liver | - |
dc.identifier.scopusid | 2-s2.0-85127300151 | - |
dc.citation.endpage | 715 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 706 | - |
dc.citation.volume | 16 | - |
dc.identifier.kciid | ART002877589 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Nayoung | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
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