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Risks of complicated acute appendicitis in patients with psychiatric disorders
DC Field | Value | Language |
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dc.contributor.author | Kim, Junmo | - |
dc.contributor.author | Yang, Chaeyoung | - |
dc.contributor.author | Joo, Hyung Joon | - |
dc.contributor.author | Park, Rae Woong | - |
dc.contributor.author | Kim, Ga Eun | - |
dc.contributor.author | Kim, Daeho | - |
dc.contributor.author | Choi, Joonho | - |
dc.contributor.author | Lee, Jun Ho | - |
dc.contributor.author | Kim, Eunkyung | - |
dc.contributor.author | Park, Seon-Cheol | - |
dc.contributor.author | Kim, Kwangsoo | - |
dc.contributor.author | Kim, Il Bin | - |
dc.date.accessioned | 2022-12-27T04:49:44Z | - |
dc.date.available | 2022-12-27T13:52:02Z | - |
dc.date.issued | 2022-12-05 | - |
dc.identifier.citation | BMC Psychiatry, 22(1):763 | ko_KR |
dc.identifier.issn | 1471-244X | - |
dc.identifier.uri | https://doi.org/10.1186/s12888-022-04428-7 | - |
dc.identifier.uri | https://hdl.handle.net/10371/187364 | - |
dc.description.abstract | Background
Acute appendicitis often presents with vague abdominal pain, which fosters diagnostic challenges to clinicians regarding early detection and proper intervention. This is even more problematic with individuals with severe psychiatric disorders who have reduced sensitivity to pain due to long-term or excessive medication use or disturbed bodily sensation perceptions. This study aimed to determine whether psychiatric disorder, psychotropic prescription, and treatment compliance increase the risks of complicated acute appendicitis. Methods The diagnosis records of acute appendicitis from four university hospitals in Korea were investigated from 2002 to 2020. A total of 47,500 acute appendicitis-affected participants were divided into groups with complicated and uncomplicated appendicitis to determine whether any of the groups had more cases of psychiatric disorder diagnoses. Further, the ratio of complicated compared to uncomplicated appendicitis in the mentally ill group was calculated regarding psychotropic dose, prescription duration, and treatment compliance. Results After adjusting for age and sex, presence of psychotic disorder (odds ratio [OR]: 1.951; 95% confidence interval [CI]: 1.218–3.125), and bipolar disorder (OR: 2.323; 95% CI: 1.194–4.520) was associated with a higher risk of having complicated appendicitis compared with absence of psychiatric disorders. Patients who are taking high-daily-dose antipsychotics, regardless of prescription duration, show high complicated appendicitis risks; High-dose antipsychotics for < 1 year (OR: 1.896, 95% CI: 1.077–3.338), high-dose antipsychotics for 1–5 years (OR: 1.930, 95% CI: 1.144–3.256). Poor psychiatric outpatient compliance was associated with a high risk of complicated appendicitis (OR: 1.664, 95% CI: 1.014–2.732). Conclusions This study revealed a close relationship in the possibility of complicated appendicitis in patients with severe psychiatric disorders, including psychotic and bipolar disorders. The effect on complicated appendicitis was more remarkable by the psychiatric disease entity itself than by psychotropic prescription patterns. Good treatment compliance and regular visit may reduce the morbidity of complicated appendicitis in patients with psychiatric disorders. | ko_KR |
dc.description.sponsorship | This work was supported by the Technology Innovation Program (or Industrial Strategic Technology Development Program) (20004927, Upgrade of CDM based Distributed Biohealth Data Platform and Development of Verification Technology) funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea), and the Bio Industrial Strategic Technology Development Program (20003883) funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea), Bio & Medical Technology Development Program of the National Research Foundation of Korea funded by the Ministry of Health and Welfare, Ministry of Science and ICT, Ministry of Trade Industry and Energy (MOTIE, Korea) Disease Control and Prevention Agency (The National Project of Bio Big Data) (NRF‑2020M3E5D7085175), and Bio & Medical Technology Development Program of the National Research Foundation funded by the Ministry of Science & ICT (No. 2021M3A9E408078412). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Psychiatric disorder | - |
dc.subject | Complicated appendicitis | - |
dc.subject | Common data model | - |
dc.subject | Treatment compliance | - |
dc.title | Risks of complicated acute appendicitis in patients with psychiatric disorders | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1186/s12888-022-04428-7 | ko_KR |
dc.citation.journaltitle | BMC Psychiatry | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2022-12-11T04:14:13Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 763 | ko_KR |
dc.citation.volume | 22 | ko_KR |
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