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Extracellular vesicles from IFN-γ-primed mesenchymal stem cells repress atopic dermatitis in mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jimin | - |
dc.contributor.author | Lee, Seul Ki | - |
dc.contributor.author | Jung, Minyoung | - |
dc.contributor.author | Jeong, Seon-Yeong | - |
dc.contributor.author | You, Haedeun | - |
dc.contributor.author | Won, Ji-Yeon | - |
dc.contributor.author | Han, Sang-Deok | - |
dc.contributor.author | Cho, Hye Jin | - |
dc.contributor.author | Park, Somi | - |
dc.contributor.author | Park, Joonghoon | - |
dc.contributor.author | Kim, Tae Min | - |
dc.contributor.author | Kim, Soo | - |
dc.date.accessioned | 2022-12-27T05:00:06Z | - |
dc.date.available | 2022-12-27T14:02:19Z | - |
dc.date.issued | 2022-12-10 | - |
dc.identifier.citation | Journal of Nanobiotechnology, 20(1):526 | ko_KR |
dc.identifier.issn | 1477-3155 | - |
dc.identifier.uri | https://doi.org/10.1186/s12951-022-01728-8 | - |
dc.identifier.uri | https://hdl.handle.net/10371/187366 | - |
dc.description.abstract | Background
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by immune dysregulation, pruritus, and abnormal epidermal barrier function. Compared with conventional mesenchymal stem cell (MSC), induced pluripotent stem cell (iPSC)-derived mesenchymal stem cell (iMSC) is recognized as a unique source for producing extracellular vesicles (EVs) because it can be obtained in a scalable manner with an enhanced homogeneity. Stimulation of iMSCs with inflammatory cytokines can improve the immune-regulatory, anti-inflammatory, and tissue-repairing potential of iMSC-derived EVs. Results Proteome analysis showed that IFN-γ-iMSC-EVs are enriched with protein sets that are involved in regulating interferon responses and inflammatory pathways. In AD mice, expression of interleukin receptors for Th2 cytokines (IL-4Rα/13Rα1/31Rα) and activation of their corresponding intracellular signaling molecules was reduced. IFN-γ-iMSC-EVs decreased itching, which was supported by reduced inflammatory cell infiltration and mast cells in AD mouse skin; reduced IgE receptor expression and thymic stromal lymphopoietin and NF-kB activation; and recovered impaired skin barrier, as evidenced by upregulation of key genes of epidermal differentiation and lipid synthesis. Conclusions IFN-γ-iMSC-EVs inhibit Th2-induced immune responses, suppress inflammation, and facilitate skin barrier restoration, contributing to AD improvement. | ko_KR |
dc.description.sponsorship | This work was supported by the Technology Development Program(S2823001) from the Ministry of SMEs and Startups (MSS, Korea). This work was also supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) grand funded by the Korea government(MSIT) (2021R1A2C2093867). In addition, this research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI18C2439). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Atopic dermatitis | - |
dc.subject | iPSC‑derived MSC | - |
dc.subject | Extracellular vesicles | - |
dc.subject | IFN-γ | - |
dc.title | Extracellular vesicles from IFN-γ-primed mesenchymal stem cells repress atopic dermatitis in mice | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1186/s12951-022-01728-8 | ko_KR |
dc.citation.journaltitle | Journal of Nanobiotechnology | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2022-12-11T04:14:55Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 526 | ko_KR |
dc.citation.volume | 20 | ko_KR |
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